Adrenomedullin is a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows slight homology with the calcitonin gene-related peptide (CGRP) (MIM.114130). It may function as a hormone in circulation control because it is found in blood in a considerable concentration.
Adrenomedullin (AM) is a regulatory peptide that is synthesized and secreted by a wide number of cells and tissues. AM is a potent vasodilator, but also exerts other functions, such as regulating cell growth and antimicrobial defence. Two receptors, L1 and calcitonin receptor-like receptor (CRLR), which are able to bind AM, have been cloned and characterized.
References
Muller FB, Muller-Rover S, Korge BP, Kapas S, Hinson JP, Philpott MP. Adrenomedullin: expression and possible role in human skin and hair growth. Br J Dermatol. 2003 Jan;148(1):30-8. PMID: 12534591