t(8;14)(q11;q32)
Strikingly, 1/4 of cases are Down syndrome patients.
Genes involved: unknown (march 2006).
CD10+ acute lymphoblastic leukemia (ALL)
chronic myelogenous leukemia (CML)
histiocyte-rich B-cell lymphoma (one case)
References
t(8;14)(q11;q32) in acute lymphoid leukemia: description of two cases. Testoni N, Zaccaria A, Martinelli G, Pelliconi S, Buzzi M, Farabegoli P, Panzica G, Tura S. Cancer Genet Cytogenet 1993; 67: 55-58. Medline 93278652
Two Down syndrome patients with an acquired translocation, t(8;14)(q11;q32), in early B-lineage acute lymphoblastic leukemia. Secker-Walker LM, Hawkins JM, Prentice HG, Mackie PH, Heerema NA, Provisor AJ. Cancer Genet Cytogenet 1993; 70: 148-150. Medline 94061814
Down syndrome, acute lymphoblastic leukemia, and t(8;14). Lee AC, Chan LC, Kwong KW. Cancer Genet Cytogenet 1996; 88: 92. Medline 96217433
A case of Down syndrome with acute lymphoblastic leukemia and t(8;14)(q11;q32). Balicek P, Rabasova J, Hak J. Atlas Genet Cytogenet Oncol Haematol. June 2001
A case of pre-B ALL with t(8;14)(q11;q32). Kerndrup GB, Rosthřj S. Atlas Genet Cytogenet Oncol Haematol. June 2001
Three further cases of t(8;14)(q11.2;q32) in acute lymphoblastic leukemia. Byatt SA, Cheung KL, Lillington DM, Mazzullo H, Martineau M, Bennett C, Roberts K, Harewood L, Sumption N, Humphreys M, Burrett J, Harrison CJ. Leukemia 2001; 15: 1304-1305 Medline 11480576
A new case of t(8;14)(q11;q32) in an acute lymphoblastic leukemia. Quilichini B, Zattara H, Casalonga F, Bastide-Alliez LA, Curtillet C, Fossat C, Michel G. Atlas Genet Cytogenet Oncol Haematol. May 2003
Acute lymphoblastic leukemia characterized by t(8;14)(q11.2;q32). Moore S, Suttle J, Bain S, Story C, Rice M. Cancer Genet Cytogenet 2003; 141: 1-4. Medline 12581891
