t(12;22)(p13;q11)
The translocation, t(12;22)(p13;q11) creates an ETV6/MN1 (TEL/MN1) fusion gene between ETV6 at 12p13 and MN1 at 22q12.3-qter.
minimally differentiated acute myeloid leukemia (AML-M0) (17476096)
See also
chromosomal translocations
ETSs genes
Chen S, Xue Y, Zhu X, Wu Y, Pan J. Related Articles, Links Minimally differentiated acute myeloid leukemia with t(12;22)(p13;q11) translocation showing primary multidrug resistance and expressing multiple multidrug-resistant proteins. Acta Haematol. 2007;118(1):38-41. Epub 2007 Apr 27. PMID: 17476096 [PubMed - in process]
van Wely KH, Meester-Smoor MA, Janssen MJ, Aarnoudse AJ, Grosveld GC, Zwarthoff EC. Related Articles, Links The MN1-TEL myeloid leukemia-associated fusion protein has a dominant-negative effect on RAR-RXR-mediated transcription. Oncogene. 2007 Mar 19; [Epub ahead of print] PMID: 17369854 [PubMed - as supplied by publisher]
Carella C, Bonten J, Rehg J, Grosveld GC. Related Articles, Links MN1-TEL, the product of the t(12;22) in human myeloid leukemia, immortalizes murine myeloid cells and causes myeloid malignancy in mice. Leukemia. 2006 Sep;20(9):1582-92. Epub 2006 Jun 29. PMID: 16810199 [PubMed - indexed for MEDLINE]
Conchon M, McManus AP, Min T, Maljaie SH, Crawford A, Brito-Babapulle V, Matutes E, Catovsky D. Related Articles, Links Two unbalanced translocations, t(12;22)(p13;q11) and t(12;?)(p13;?), in an aggressive chronic B-cell leukemia: TEL gene analysis using FISH. Cancer Genet Cytogenet. 1997 Jun;95(2):137-40. PMID: 9169030 [PubMed - indexed for MEDLINE] 18: Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A, et al. Related Articles, Links Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene. 1995 Apr 20;10(8):1511-9. Erratum in: Oncogene 1995 Aug 17;11(4):809. PMID: 7731705 [PubMed - indexed for MEDLINE]