Tumoral deletions

• translocation/deletion associations
  18 June 2007

  Examples
  deletion of the MLL gene in acute lymphoblastic leukemias (ALLs) (#14527352#)
  References
  Zhang L, Parkhurst JB, Kern WF, Scott KV, Niccum D, Mulvihill JJ, Li S. Chromosomal changes detected by fluorescence in situ hybridization in patients with acute lymphoblastic leukemia. Chin Med J (Engl). 2003 Sep;116(9):1298-303. PMID: #14527352#

• tumoral 8q24 deletion
  18 May 2007

  Target genes
  MYC
  References
  Christacos NC, Sherman L, Roy A, DeAngelo DJ, Dal Cin P. Is the cryptic interstitial deletion of 8q24 surrounding MYC a common mechanism in the formation of double minute chromosome? Cancer Genet Cytogenet. 2005 Aug;161(1):90-2. PMID: #16080965#

• tumoral 20q deletion
  18 May 2007

  Tumors
  myeloid malignancies (#16157208#)
  See also
  20q LOH 20q11 LOH
  References
  Ligon AH, DeAngelo DJ, Atkins L, Dal Cin P. Isochromosome of a deleted 20q may be a relatively common abnormality in myeloid malignancies. Cancer Genet Cytogenet. 2005 Oct 1;162(1):89-91. PMID: #16157208#

• del(1)(p11p36)
  18 May 2007

  Tumors
  uterine leiomyoma (#16320247#)
  References
  Christacos NC, Quade BJ, Dal Cin P, Morton CC. Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features. Genes Chromosomes Cancer. 2006 Mar;45(3):304-12. PMID: #16320247#

• del(5q)
  19 March 2007

  del(5)(q13q33)

• del(7q)
  13 February 2007

  Tumors
  uterine leiomyomas (#17285575#)
  myelodysplastic syndrome
  acute myeloid leukemia (AML)
  See also
  7q22-q31 LOH
  References
  Vanharanta S, Wortham NC, Langford C, El-Bahrawy M, van der Spuy Z, Sjoberg J, Lehtonen R, Karhu A, Tomlinson IP, Aaltonen LA. Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region. Genes Chromosomes Cancer. 2007 Feb 6; PMID: (...)

• del(11q)
  31 January 2007

  deletion 11q

• del(22q)
  23 January 2007

  Tumors
  meningiomas
  See also
  monosomy 22 (-22)
  tumoral deletions

• del(11)(p13)
  23 January 2007

  Tumors
  Wilms tumor
  See also
  tumoral deletions

• del(9)(p13)
  23 January 2007

  Target gene
  PAX5
  Tumors
  malignant melanoma
  acute lymphoblastic leukemia (ALL)
  See also
  tumoral deletions

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