Tumoral deletions

• del(11)(q22-q23)
  28 November 2007

  11q22-q23 deletion

• del(13)(q14.2)
  28 November 2007

  13q14 deletion

• del(9)(p21)
  19 September 2007

  9p21 deletion

• 11q23 deletion
  19 September 2007

  Tumors
  mantle cell lymphoma (#16382446#)
  chronic lymphocytic leukemia (#15672409#, #16418492#)
  References
  Guikema JE, de Boer-Bergsma RW, Akkermans K, Schuuring E, Kluin PM. H2AX is not affected in mantle cell lymphoma with 11q23 deletion. Genes Chromosomes Cancer. 2006 Apr;45(4):426-7. PMID: #16382446#
  Kröber A, Bloehdorn J, Hafner S, Bühler A, Seiler T, Kienle D, Winkler D, Bangerter M, Schlenk RF, Benner A, Lichter P, Döhner H, Stilgenbauer S. Additional genetic high-risk features (...)

• 6q23.3 deletion
  10 September 2007

  Tumors
  testicular diffuse large B-cell lymphoma (testicular DLBCL)
  References
  Bosga-Bouwer AG, Kok K, Booman M, Boven L, van der Vlies P, van den Berg A, van den Berg E, de Jong B, Poppema S, Kluin P. Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. Genes Chromosomes Cancer. 2006 Oct;45(10):976-81. PMID: (...)

• 6q16.3-q21 deletion
  10 September 2007

  Tumors
  testicular diffuse large B-cell lymphoma (testicular DLBCL)
  References
  Bosga-Bouwer AG, Kok K, Booman M, Boven L, van der Vlies P, van den Berg A, van den Berg E, de Jong B, Poppema S, Kluin P. Array comparative genomic hybridization reveals a very high frequency of deletions of the long arm of chromosome 6 in testicular lymphoma. Genes Chromosomes Cancer. 2006 Oct;45(10):976-81. PMID: (...)

• homozygous deletions
  29 August 2007

  HDs

• 7q34 deletion
  26 June 2007

  Somatic interstitial deletions of chromosome segment 7q34 in uterine leiomyomas.
  Tumors
  uterine leiomyomas (#17285575#)
  See also
  7q deletion
  7q LOH 7q22-q31 LOH
  References
  Vanharanta S, Wortham NC, Langford C, El-Bahrawy M, van der Spuy Z, Sjoberg J, Lehtonen R, Karhu A, Tomlinson IP, Aaltonen LA. Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region. Genes Chromosomes (...)

• 7q22-q31 deletion
  26 June 2007

  Somatic interstitial deletions of chromosome segment 7q22-q31 in uterine leiomyomas are a frequent event, thought to be indicative of a tumor suppressor gene in the region.
  The minimum deleted region has been refined at 7q22.3-q31 to 2.79 Mbp. (#17285575#)
  Tumors
  uterine leiomyomas (#17285575#)
  See also
  7q deletion
  7q LOH 7q22-q31 LOH
  References
  Vanharanta S, Wortham NC, Langford C, El-Bahrawy M, van der Spuy Z, Sjoberg J, Lehtonen R, Karhu A, Tomlinson IP, Aaltonen LA. (...)

• der(9) deletion
  18 June 2007

  About 95% of the CML patients with chronic myeloid leukemia (CML) have a Philadelphia chromosome resulting from a reciprocal translocation between bands 9q34 and 22q11.2 that juxtaposes the 3’ region of the ABL gene to the 5’ region of BCR.
  Over the past few years, submicroscopic deletions due to the loss of sequences proximal to chromosome 9 breakpoint or distal to chromosome 22 breakpoint have been found using fluorescence in situ hybridization (FISH).
  Der(9) deletions are seen in 10-15% (...)

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