Regional amplifications

• 8q12 amplification
  12 June 2006

  Target gene
  PLAG1
  Tumors
  hepatoblastoma

• 7q21 amplification
  5 January 2006

  7q21-q22 amplification, 7q21 amplicon

• 20q13 amplification
  5 January 2006

  20q12-q13 amplification, 20q13 amplicon

• 15q25-26 amplification
  7 October 2005

  Target genes:
  IGF1R
  Tumors
  IGF1R overexpression by 15q25-26 amplicon amplification in tumors rhabdomyosarcomas (#11807989#) embryonal rhabdomyosarcoma alveolar rhabdomyosarcoma
  increased copy number at chromosome 15q26.3 correlation with Wilms tumor relapse (#17145858#)
  See also
  15q gain
  References
  Natrajan R, Reis-Filho JS, Little SE, Messahel B, Brundler MA, Dome JS, Grundy PE, Vujanic GM, Pritchard-Jones K, Jones C. Blastemal expression of type I insulin-like growth (...)

• amplicons
  15 June 2005

  Exemples
  1q21-q22 amplicon
  12q13-12q14 amplicon target genes: CDK4 (12q14)
  15q25-26 amplicon target genes: IGF1R
  References
  Bignell GR, Santarius T, Pole JC, Butler AP, Perry J, Pleasance E, Greenman C, Menzies A, Taylor S, Edkins S, Campbell P, Quail M, Plumb B, Matthews L, McLay K, Edwards PA, Rogers J, Wooster R, Futreal PA, Stratton MR. Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res. 2007 Sep;17(9):1296-303. (...)

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