Regional amplifications

• 8q24.3 amplification
  28 June 2007

  Tumors
  cervical squamous cell carcinoma (CSCC)
  References
  Narayan G, Bourdon V, Chaganti S, Arias-Pulido H, Nandula SV, Rao PH, Gissmann L, Durst M, Schneider A, Pothuri B, Mansukhani M, Basso K, Chaganti RS, Murty VV. Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes. Genes Chromosomes Cancer. 2007 Apr;46(4):373-84. PMID: (...)

• 8q24 amplification
  28 June 2007

  Subregions
  8q24.21 amplification head and neck squamous cell carcinoma (HNSCC)
  8q24.3 amplification cervical squamous cell carcinoma (CSCC)
  Driver genes
  CMYC
  PVT1
  See also
  Oncobase
  References
  Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Cancer Res. 2010 Jan (...)

• iAMP21
  28 June 2007

  Intrachromosomal amplification of chromosome 21 (iAMP21) involves amplification of the RUNX1 gene and duplication of chromosome 21, dup(21q).
  iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in several tumors, as B-lineage acute lymphoblastic leukemia (ALL).
  It defines a new cytogenetic subgroup in B-lineage acute lymphoblastic leukemia (ALL) with a poor prognosis.
  Driver genes
  RUNX1
  See also
  dup(21q)
  References
  Robinson HM, Harrison CJ, (...)

• 8p12 amplification
  14 June 2007

  8p12 amplicons

• HPV-18/MYC amplicon
  14 June 2007

  The unscheduled replication origin activation at inserted HPV-18 viral DNA sequences triggers DNA amplification and the subsequent overexpression of the MYC oncogene.
  References
  Conti C, Herrick J, Bensimon A. Unscheduled DNA replication origin activation at inserted HPV 18 sequences in a HPV-18/MYC amplicon.
  Genes Chromosomes Cancer. 2007 Apr 19;46(8):724-734 PMID: #17444495#

• 12q amplification
  12 June 2007

  12q amplicons

• 11q14 amplification
  1 June 2007

  11q14 amplicon

• 2p25-p23 amplification
  1 June 2007

  Tumors
  neuroepithelial tumors

• 12q13-15 amplification
  1 June 2007

  12q13-q15 amplification, 12q14-15 amplicon

• 18q11.2 amplification
  1 June 2007

  Tumors
  pancreatic carcinomas pancreatic adenocarcinomas
  Candidate genes
  GATA6
  TAGE1

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