Regional amplifications

• 8q21 amplification
  28 February 2017

  Copy number increases restricted to chromosome 8q21 has been described in human cancers, which were reported most frequently in breast cancer.
  Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome. (#20139910#)
  Open references
  Challenges in identifying candidate amplification targets in human cancers: chromosome 8q21 as a case study.
  Byrne JA, Chen Y, Martin La Rotta N, Peters GB.
  Genes Cancer. 2012 Feb;3(2):87-101. (...)

• 19q13.42 amplification
  13 August 2012

  19q13 amplification
  Tumors
  embryonal tumor with abundant neuropil and true rosettes (ETANTR)
  References
  Embryonal tumor with abundant neuropil and true rosettes: a report of three cases of a rare tumor, with an unusual case showing rhabdomyoblastic and melanocytic differentiation. Al-Hussaini M, Abuirmeileh N, Swaidan M, Al-Jumaily U, Rajjal H, Musharbash A, Hashem S, Sultan I. Neuropathology. 2011 Dec;31(6):620-5. PMID: #22103481#
  Embryonal tumor with abundant neuropil and true (...)

• 14q11.2 amplification
  13 March 2012

  Tumors
  hepatoblastoma (#18271875#)

• 7q34 amplification
  13 March 2012

  Tumors
  hepatoblastoma (#18271875#)

• 6p12 amplification
  25 November 2011

  Target genes
  VEGFA
  Tumors
  colorectal cancer (colorectal adenocarcinoma)
  References
  VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal patients. Vlajnic T, Andreozzi MC, Schneider S, Tornillo L, Karamitopoulou E, Lugli A, Ruiz C, Zlobec I, Terracciano L. Mod Pathol. 2011 Nov;24(11):1530. PMID: #22048234#

• 19p13 amplification
  26 May 2011

  Tumors
  ovarian high-grade serous carcinoma. (#21240255#)
  Pathology
  Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma. (#21240255#)
  Driver genes
  NACC1
  References
  Amplification of the ch19p13.2 NACC1 locus in ovarian high-grade serous carcinoma. Shih IeM, Nakayama K, Wu G, Nakayama N, Zhang J, Wang TL. Mod Pathol. 2011 May;24(5):638-45. PMID: (...)

• 4p12 amplification
  21 April 2010

  Target genes - driver genes
  PDGFRA
  Tumors (Examples)
  non-small cell lung cancer (#19755855#)
  References
  Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M. Cancer Biol Ther. 2009 Nov;8(21):2042-50. PMID: (...)

• 12p13 amplification
  2 February 2010

  Driver genes
  WNT5B
  Tumors
  pediatric malignant astrocytoma (#20068183#)
  References
  Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Cancer Res. 2010 Jan 15;70(2):512-9. PMID: (...)

• 3p11-12 amplification
  23 April 2009

  Tumors
  myxoinflammatory fibroblastic sarcoma (#19199331#)
  haemosiderotic fibrolipomatous tumour (#19199331#)
  References
  Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions. Hallor KH, Sciot R, Staaf J, Heidenblad M, Rydholm A, Bauer HC, Aström K, Domanski HA, Meis JM, Kindblom LG, Panagopoulos I, Mandahl N, Mertens F. J Pathol. 2009 Apr;217(5):716-27. PMID: (...)

• 17q23-25 amplification
  10 October 2008

  Tumors
  rhabdomyosarcomas
  References
  Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Baker KS, Sorensen P, Barr FG. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer. 2002 Mar;33(3):310-21. PMID: (...)

0 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80