Prostate

• central zone
  9 February 2019

  CZ
  Definition : CZ surrounds the ejaculatory ducts. The central zone accounts for roughly 2.5% of prostate cancers; these cancers tend to be more aggressive and more likely to invade the seminal vesicles.
  Glands of central zone at the base of the prostate can mimic high-grade PIN architecturally.
  There is nuclear crowding and pseudostratification with tufted, papillary and even cribriform areas within the glands.
  Central zone glands may sometimes be seen at the end of a prostate biopsy (...)

• prostatic adenocarcinoma with papillary pattern
  25 January 2019

  prostate adenocarcinoma with papillary pattern
  Examples
  prostatic ductal adenocarcinoma
  Differential diagnosis
  papillary urothelial carcinoma

• prostatic atypical adenomatous hyperplasia
  29 August 2018

  prostatic adenosis PO
  Definition: A microscopic proliferation of small glands with minimal atypia; may be mistaken for low grade adenocarcinoma. It is sound almost exclusively in transition zone (2% of TURPs, < 1% of core biopsies).
  Microscopy
  The glands are variable in size and show round, oval, or irregular lumina. The cytoplasm is pale in contrast to the amphophilic cytoplasm usually seen in cancer.
  The nuclei are not enlarged appreciably and prominent nucleoli are not (...)

• PIN-like carcinoma
  29 August 2018

  Definition: Prostatic intraepithelial neoplasia like (PIN-like ductal) carcinoma are rare tumors characterized by crowded, often cystically dilated glands architecturally resembling high-grade prostatic intraepithelial neoplasia, lined by malignant pseudostratified columnar epithelium.
  The largest prior series studied 9 radical prostatectomies (RPs) and suggested a behavior similar to Gleason score 6.
  Paywall references
  PIN-like (Ductal) Adenocarcinoma of the Prostate. Paulk A, (...)

• prostatic adenocarcinoma with focal pleomorphic giant cells
  17 July 2018

  Prostatic adenocarcinoma with focal pleomorphic giant cell features has a dismal prognosis. (#29944471#)
  Paywall references
  Prostatic Adenocarcinoma With Focal Pleomorphic Giant Cell Features: A Series of 30 Cases. Alharbi AM, De Marzo AM, Hicks JL, Lotan TL, Epstein JI. Am J Surg Pathol. 2018 Jun 25. doi:10.1097/PAS.0000000000001112. PMID: #29944471#

• prostatic phyllodes tumor
  26 March 2018

  Phyllodes Tumor of the Prostate
  Phyllodes tumor of the prostate is a rare mesenchymal tumor conventionally regarded as a stromal tumor of undetermined malignant potential. While the initial presentation is that of urinary obstruction and/or hematuria, the subsequent clinical behavior is thought to be a function of stromal cellularity and cytologic changes of malignancy.
  Of histologic interest, the epithelial component of this tumor varies, including intestinal metaplasia.
  Paywall (...)

• prostatic urethra
  4 February 2018

  WKP
  Definition : The prostatic urethra, the widest and most dilatable part of the urethra canal, is about 3 cm. long.
  It runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; the form of the canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous (...)

• prostatic small cell neuroendocrine carcinoma
  20 November 2017

  small cell neuroendocrine carcinoma of the prostate
  Molecular biology
  FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate. [#28621319#)

• atypical small acinar proliferation
  30 August 2017

  atypical glands in prostate biopsy PO WP
  Atypical small acinar proliferation (ASAP) occurs in approximately 5% of prostate biopsies.
  Approximately 30-40% of patients with ASAP may develop prostate cancer (PCa) within a 5-year period.
  Current guidelines recommend a repeat biopsy within 3-6 months after the initial diagnosis.
  Images
  http://webpathology.com/image.asp?case=22&n=1
  example : (ASAP), suspicious for but not diagnostic of malignancy; Focal Glandular Atypia (FGA) and (...)

• prostate transition zone
  25 July 2017

  The prostate gland contains three major glandular regions :
  the peripheral zone ,
  the central zone,
  the transition zone .
  The central zone is relatively resistant to carcinoma and other disease; the transition zone is the main site of origin of prostate hyperplasia. There are also several important non-glandular regions concentrated in the anteromedial portion of the gland.
  Each glandular zone has specific architectural and stromal features. In all zones, both ducts and acini are (...)

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