Thyroid gland

• oncocytic medullary carcinoma
  20 April 2020

  Oncocytic medullary carcinomas can be difficult to recognise. These lesions usually have a nesting or insular architecture and the cells are polygonal rather than having the spindle shaped morphology of the usual variant.
  The nuclei resemble neuroendocrine nuclei (round to oval with salt and pepper chromatin).
  See also
  thyroid gland anomalies

• thyroid fibrous lesions
  20 April 2020

  See also
  thyroid gland anomalies

• poorly differentiated thyroid carcinoma
  25 October 2019

  Images
  Insular growth pattern of poorly differentiated carcinoma of thyroid (insular carcinoma before) : https://twitter.com/Patholwalker/status/1187628076944875521
  See also
  thyroid tumors thyroid carcinomas

• cribriform morular variant of papillary thyroid carcinoma
  25 October 2019

  CMV-PTC
  The cribriform morular variant is associated with APC mutations, as found in familial adenomatous polyposis. The prognosis is similar to conventional papillary carcinoma.
  PTC, cribriform morular variant has tall cells, nuclei with grooves and pseudoinclusions typical of PTC, and squamoid metaplasia. The cribriform morular variant is associated with APC mutations, as found in familial adenomatous polyposis. The prognosis is similar to conventional papillary (...)

• thyroid trabecular tumors
  28 April 2019

  Examples
  Trabecular growth pattern of poorly differentiated carcinoma of thyroid gland https://twitter.com/Patholwalker/status/1122114136958128128 https://twitter.com/Patholwalker/status/1451106815945543687
  See also
  trabecular architecture / trabecular pattern

• giant cell variant of medullary thyroid carcinoma
  13 March 2019

  Examples
  giant cell variant of Medullary thyroid carcinoma (MTC) MTC variants typically carry the same prognosis as the conventional type. DD : ATC and Mets to the thyroid. https://twitter.com/sza_jhcyto/status/1105511218536738818
  Paywall references
  Fine needle aspiration cytology of medullary carcinoma of the thyroid with a focus on rare variants: a review of 78 cases. Kaushal S, Iyer VK, Mathur SR, Ray R. Cytopathology. 2011 Apr;22(2):95-105. doi:10.1111/j.1365-2303.2010.00747.x. (...)

• thyroid follicular hyperplasia
  11 March 2019

  Examples
  Graves disease / Basedow disease hyperplastic thyroid follicles with papillary infolding, colloid is decreased, w/ peripheral scalloping. https://twitter.com/Ho_Khanh_MD/status/1105093144675315717
  See also
  papillary infolding of thyroid follicles
  anomalies of colloid decreased colloid increased colloid
  peripheral scalloping. https://twitter.com/Ho_Khanh_MD/status/1105093144675315

• lacunar nuclei
  9 March 2019

  Examples
  Papillary thyroid carcinoma. Grooves & classic "orphan Annie eye" (empty round nuclei) https://twitter.com/JMGardnerMD/status/840925854632927232 https://twitter.com/CTaraboantaMD/status/848971172368662528
  lacunar nuclei https://twitter.com/andy19801210/status/1103527277323640832
  See also
  nuclear anomalies

• follicular thyroid tumors
  14 November 2018

  thyroid tumors with follicular architecture
  Definition: Thyroid tumors with follicular architecture encompass a considerable array of distinct entities. These lesions share significant morphologic overlap, but portend different prognostic and therapeutic implications.
  Due to their similar growth patterns, distinction between these tumors can be difficult; remarkable interobserver variability exists, even between expert endocrine pathologists.
  Given the diagnostic challenges associated (...)

• anaplastic thyroid carcinoma
  17 June 2017

  Molecular biology
  Mutations in anaplastic thyroid carcinoma: p53 (70%), beta-catenin (60%) and ras (50%). If the carcinoma has BRAF V600E, then it is arising from papillary thyroid carcinoma.
  Variants
  anaplastic thyroid carcinoma with osteoclast-type giant cells
  rhabdoid anaplastic thyroid carcinoma

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