Breast

• breast cancer susceptibility
  8 February 2012

  Candidate genes
  BRCA1
  BRCA2
  FGFR2
  TNRC9
  MAP3K1
  LSP1
  10q23.32-q25.3 locus (#17171685#)
  Gene-gene interactions in breast cancer susceptibility
  Through mutational analyses in many individuals, four interactions (defined as departures from a multiplicative model) have been described between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2.
  The interactions are such that the resultant risk of breast cancer is lower than the multiplicative (...)

• PI3K-associated mammary carcinoma
  8 February 2012

  PI3K-associated breast cancer; Phosphatidylinositol 3-kinase breast cancer
  Open references
  Elevated PI3K signaling drives multiple breast cancer subtypes. Adams JR, Schachter NF, Liu JC, Zacksenhaus E, Egan SE. Oncotarget. 2011 Jun;2(6):435-47. PMID: #21646685# (free)
  Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Baselga J. Oncologist. 2011;16 Suppl 1:12-9. PMID: #21278436# [Free]
  Key signalling nodes in mammary gland development and cancer. Signalling (...)

• ER positive mammary carcinoma
  8 February 2012

  ER positive breast cancer
  See also
  mammary carcinoma (breast cancer)

• breast pathology
  20 January 2012

  mammary pathology
  Web sites
  http://www.breastpathology.info/

• mammary MALT lymphoma
  6 December 2011

  Mammary marginal zone B-cell lymphoma

• mammary diffuse large B-cell lymphoma
  6 December 2011

  Mammary diffuse large B cell lymphoma, Mammary DLBCL)

• sentinel lymph node for mammary carcinoma
  28 November 2011

  sentinel lymph nodes for breast cancer; mammary carcinoma metastasis in axilary lymph node
  Node stage Criteria pN(mol+) Tumor cells detected by molecular methods only. pN0(i+) Isolated tumor cells < 0.2 mm or < 200 cells pN1mi Tumor cells >= 0.2 mm and < 2 mm pN1a 1 - 3 lymph nodes,at least one focus >= 2mm.
  IHC
  Cytokeratin 19 (CK19 or KRT19) messenger RNA amplification
  Sentinel node (SN) pathologic analysis shows great limitations related to (...)

• mammary invasive lobular carcinoma
  9 February 2011

  breast invasive lobular carcinoma; invasive lobular carcinoma of the breast; mammary infiltrating lobular carcinoma; lobular carcinoma of the breast: mammary invasive lobular carcinoma; infiltrating lobular carcinoma of the breast PO WPA
  Definition: Invasive lobular carcinoma shows single file infiltrative neoplastic cells, which are negative for E-cadherin and shows cytoplasmic p120 cadherin as opposed to surface p120.
  The lesion usually presents as a palpable mass, and mammography (...)

• mammary intracystic papillary carcinoma
  22 November 2010

  Intracystic Papillary Carcinoma of the Breast

• mammary invasive ductal carcinoma
  18 November 2010

  Invasive ductal carcinomas of the breast; mammary invasive ductal carcinoma; mammary infiltrative ductal carcinoma; mammary infiltrating ductal carcinoma; IDC
  Definition: Invasive ductal carcinoma has malignant infiltrating glands with a desmoplastic stroma, and is negative for myoepithelial cell markers, such as p63 and SMA. It is graded by the Nottingham grading system, which depends on tubule formation, nuclear pleomorphism, and mitotic count.
  Links (...)

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