Blood and immunity

• mature B-cell leukemias
  8 December 2003
• myelodysplastic/myeloproliferative neoplasms
  8 December 2003

  myelodysplastic syndrome, myelodysplastic diseases; myelodysplasia; (MDS/MPN) myelodysplastic syndromes

• myeloproliferative neoplasms
  8 December 2003

  chronic myeloproliferative disorders; myeloproliferative disease; chronic myeloproliferative diseases; chronic myeloproliferative neoplasms
  /WP/
  Definition: The myeloproliferative diseases (MPDs) or myeloproliferative neoplasms (MPNs) are a group of diseases of the bone marrow in which excess cells are produced.
  The myeloproliferative diseases (MPDs) are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the (...)

• myelodysplasia
  8 December 2003

  WKP
  See also : myelodysplastic syndromes (MDS).
  The features generally used to define a MDS are:
  blood cytopenias;
  ineffective hematopoiesis;
  dyserythropoiesis;
  dysgranulopoiesis;
  dysmegakaropoiesis;
  increased myeloblast.
  Bone marrow aspirate and peripheral blood smear
  Dysplasia can affect all three lineages seen in the bone marrow. The best way to diagnose dysplasia is by morphology and special stains (PAS) used on the bone marrow aspirate and peripheral blood smear. (...)

• myeloid sarcoma
  5 December 2003

  chloroma, extramedullary myeloid tumor, granulocytic sarcoma
  Definition: Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site.
  Extramedullary accumulation of myeloblasts or immature myeloid cells form tumors called myeloid sarcoma in the WHO classification. Such tumors develop in lymphoid organs, bone (skull, orbit, etc.), skin, soft tissue, various mucosae and organs, and the CNS. The correct diagnosis of MS is important for (...)

• histiocytic sarcoma
  5 December 2003

  malignant histiocytosis, true histiocytic malignancy
  Synopsis
  pleomorphic histiocytic cells: medium cells, large cells and the giant cells expressing CD68, lysozyme and S100 protein.
  erythrophagocytosis (erythrophagocytic histiocytosis)
  lymphocytophagocytosis
  Forms
  localized forms (localized histiocytic sarcoma)
  spleen (splenic histiocytic sarcoma)
  central nervous system (#12548175#)
  systemic histiocytic sarcoma or disseminated histiocytic sarcoma
  malignant histiocytosis (...)

• neutrophils
  4 December 2003

  neutrophilic polymorphonuclear cells, neutrophilic granulocytes, Adj. neutrophilic
  Pathology
  neutrophilic infiltration
  neutrophilic deficiency
  neutrophilic proliferations
  neutrophilic disorders
  See also
  granulocytes diapedesis
  neutrophil phagocytosis
  neutrophil differentatiation
  neutrophil development
  polymophonuclear cells neutrophils eosinophils basophils (...)

• lymphocyte activation
  2 December 2003

  References
  Krawczyk C, Penninger JM. Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol. 2001 May;11(5):212-20. PMID: #11316610#

• lymphocyte migration
  1 December 2003

  References
  Reif K, Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol. 2002 Aug;12(8):368-73. PMID: #12191913#

• lymphocytes
  1 December 2003

  Definition: White blood cells that are responsible for humoral and cellular immunity.
  Types
  T lymphocytes
  B lymphocytes
  Lymphocyte morphology
  small lymphocytes small non-cleaved lymphocytes small cleaved lymphocytes
  large non-cleaved lymphocytes
  associated cells follicular dendritic cell (FDC)
  See also
  lymphocyte migration
  References
  O’Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol. 2000 Dec;10(12):542-50. PMID: (...)

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