Circulating tumor cells

• CTCs and stemness
  18 March 2015

  Open References
  Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer. Papadaki MA, Kallergi G, Zafeiriou Z, Manouras L, Theodoropoulos PA, Mavroudis D, Georgoulias V, Agelaki S. BMC Cancer. 2014 Sep 3;14:651. doi:10.1186/1471-2407-14-651. PMID: #25182808# (...)

• shear stress
  18 March 2015

  WP
  Shear stress in fluids
  Any real fluids (liquids and gases included) moving along solid boundary will incur a shear stress on that boundary. The no-slip condition dictates that the speed of the fluid at the boundary (relative to the boundary) is zero, but at some height from the boundary the flow speed must equal that of the fluid. The region between these two points is aptly named the boundary layer.
  For all Newtonian fluids in laminar flow, the shear stress is proportional to the (...)

• anoikis
  18 March 2015

  Frisch and Francis, Journal of Cell Biology, 1994. WP
  Anoikis is a form of programmed cell death (apoptosis) that is induced by anchorage-dependent cells detaching from the surrounding extracellular matrix (ECM).
  Usually cells stay close to the tissue to which they belong since the communication between proximal cells as well as between cells and ECM provide essential signals for growth or survival.
  When cells are detached from the ECM, there is a loss of normal cell–matrix (...)

• DTCs in the bone marrow
  18 March 2015

  DTCs in the bone marrow have been detected for all solid tumor types, suggesting that this compartment might be a preferred reservoir for blood-borne DTC from where they may re-disseminate to other distant organs such as liver or lungs where better growth conditions may exist.
  For example, DTCs are prognostic markers in colorectal cancer even though bone metastases are very rare in this cancer type (Lindemann et al, 1992; Pantel et al, 1993).
  In breast cancer, where bone metastases are (...)

• CTCs and epithelial-mesenchymal transition
  18 March 2015

  CTCs and EMT
  Open references
  Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer. Papadaki MA, Kallergi G, Zafeiriou Z, Manouras L, Theodoropoulos PA, Mavroudis D, Georgoulias V, Agelaki S. BMC Cancer. 2014 Sep 3;14:651. doi:10.1186/1471-2407-14-651 . PMID: #25182808# [Free]
  Interplay of Stem Cell Characteristics, EMT, and Microtentacles in Circulating Breast Tumor (...)

• CTCs and targeted therapy
  18 March 2015

  Open References
  Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Science. 2014 Jul 11;345(6193):216-20. doi:10.1126/science.1253533 . PMID: #25013076# [Free]
  References
  In (...)

• culture of CTCs
  17 March 2015

  In vitro expansion of tumour cells derived from blood; CTCs expansion
  Open References
  Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Science. 2014 Jul 11;345(6193):216-20. (...)

• limitations of CTCs detection
  17 March 2015

  Despite the numerous scientific publications related to CTC detection in cancer patients, the physician does not use this biomarker in routine clinical practice. This can be explained by the large number of methods available for CTC detection and by the difficulty of the physician and the biologist to select the optimal method for use.
  Lung cancer
  It is noteworthy that the only FDA approved method for CTC detection, the CellSearch method (Janssen Diagnostics Company, USA), has been (...)

• circulating tumor microemboli
  17 March 2015

  CTMs
  CTCs can circulate in the bloodstream of lung cancer patients as single cells or as aggregates [called circulating tumor microemboli (CTMs)]. In this regard, the phenotype of single or aggregated CTCs can be different and may present different levels of potential aggressiveness.

• self-seeding
  17 March 2015

  References
  Kim MY, Oskarsson T, Acharyya S, et al. Tumor self-seeding by circulating cancer cells. Cell 2009;139:1315-26. [http://www.ncbi.nlm.nih.gov/pubmed/20064377]

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