Fusion genes

• CRTC3-MAML2
  3 November 2016

  Pathology
  CRTC3-MAML2 in mucoepidermoid carcinoma
  See also
  CRTCs
  See also
  Warthin-like Mucoepidermoid Carcinoma: A Combined Study of Fluorescence In Situ Hybridization and Whole-slide Imaging. Ishibashi K, Ito Y, Masaki A, Fujii K, Beppu S, Sakakibara T, Takino H, Takase H, Ijichi K, Shimozato K, Inagaki H. Am J Surg Pathol. 2015 Nov;39(11):1479-87. doi:10.1097/PAS.0000000000000507.
  PMID: (...)

• EWSR1-KLF15
  3 November 2016

  Molecular biology
  EWSR1-KLF15 fusion gene in : renal myoepithelial carcinoma
  See also
  EWSR1
  KLF15
  Paywall references
  Expanding the Spectrum of Renal Tumors in Children: Primary Renal Myoepithelial Carcinomas With a Novel EWSR1-KLF15 Fusion. Cajaiba MM, Jennings LJ, Rohan SM, Leuer KM, Anagnost MR, Fahner JB, Fulton BK, Geller JI, Perlman EJ. Am J Surg Pathol. 2016 Mar;40(3):386-94. doi:10.1097/PAS.0000000000000545.
  PMID: (...)

• FUS-KLF17
  2 November 2016

  Pathology
  KLF17 gene fusion in myoepithelial tumor FUS-KLF17 fusion gene in myoepithelial tumor (#26645726#) EWSR1-KLF17 fusions in myoepithelial tumor (#25706482#)
  See also
  ZNFs
  Open references
  Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors. Huang SC, Chen HW, Zhang L, Sung YS, Agaram NP, Davis M, Edelman M, Fletcher CD, Antonescu CR. Genes Chromosomes Cancer. 2015 May;54(5):267-75. doi:10.1002/gcc.22240.
  PMID: #25706482# Free
  Paywall References
  Thoracic (...)

• EWSR1-ZNF44
  2 November 2016

  Pathology
  EWSR1-ZNF44 fusion gene in : myoepithelial tumors (#26645726#)
  See also
  ZNFs
  Paywall References
  Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature. Leduc C, Zhang L, Öz B, Luo J, Fukuoka J, Antonescu CR, Travis WD. Am J Surg Pathol. 2016 Feb;40(2):212-23. doi:10.1097/PAS.0000000000000560. PMID: #26645726#

• BCOR-MAML3
  1 November 2016

  WKP
  Pathology
  BCOR-MAML3 fusion gene in Ewing-like saroma (#26752546#)
  Paywall references
  Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas. Specht K, Zhang L, Sung YS, Nucci M, Dry S, Vaiyapuri S, Richter GH, Fletcher CD, Antonescu CR. Am J Surg Pathol. 2016 Apr;40(4):433-42. doi:10.1097/PAS.0000000000000591. PMID: (...)

• ALK-STRN
  1 November 2016

  STRN-ALK WKP
  Pathology
  ALK-STRN fusion gene in renal cell carcinoma (RCC) Anaplastic lymphoma kinase (ALK) translocation renal cell carcinomas (RCCs) have been reported: ALK-rearranged renal cell carcinoma (RCC) Striatin is a protein that in humans is encoded by the STRN gene.
  Paywall references
  Two Cases of Renal Cell Carcinoma Harboring a Novel STRN-ALK Fusion Gene. Kusano H, Togashi Y, Akiba J, Moriya F, Baba K, Matsuzaki N, Yuba Y, Shiraishi Y, Kanamaru H, Kuroda N, Sakata (...)

• PDGFRB-ROS1
  1 November 2016

  ROS1-PDGFRB WKP
  Pathology
  PDGFRB-ROS1 gene fusion between ROS1 and PDGFRB in : ALK-negative inflammatory myofibroblastic tumor
  Open references
  Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement. Antonescu CR, Suurmeijer AJ, Zhang L, Sung YS, Jungbluth AA, Travis WD, Al-Ahmadie H, Fletcher CD, Alaggio R. Am J Surg Pathol. 2015 Jul;39(7):957-67. doi:10.1097/PAS.0000000000000404.
  PMID: (...)

• CIC-DUX4
  1 November 2016

  DUX4-CIC
  Molecular biology
  CIC-DUX4 gene fusion in Ewing-like sarcoma Ewing-like sarcomas with t(4;19)(q35;q13) Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. fusion gene between DUX4 at 4q35 (MIM.606009) and CIC at 19q35 by t(4;19)(q35;q13) (#16717057#) CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a (...)

• BCOR-ZC3H7B
  1 November 2016

  ZC3H7B-BCOR
  Tumors
  BCOR-ZC3H7B fusion gene in high-grade endometrial stromal sarcoma (#27631520#) Endometrial stromal sarcomas (ESS) are often underpinned by recurrent chromosomal translocations resulting in the fusion of genes involved in epigenetic regulation. YWHAE-NUTM2 rearrangements also associated with distinctive high-grade ESS and aggressive clinical behavior. ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade ESS and shares significant morphologic overlap with (...)

• ZFP36-FOSB
  31 October 2016

  WKP
  Pathology
  ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with atypical features. (#25043949#)
  Open references
  Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics.
  Sugita S, Hirano H, Kikuchi N, Kubo T, Asanuma H, Aoyama T, Emori M, Hasegawa T. Diagn Pathol. 2016 Aug 11;11(1):75. doi:10.1186/s13000-016-0530-2.
  PMID: #27515856# Free
  ZFP36-FOSB fusion defines a subset of epithelioid hemangioma with (...)

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