Signaling pathways

Open references
Cotargeting survival signaling pathways in cancer. Grant S. J Clin Invest. 2008 Sep;118(9):3003-6. PMID: #18725993# [Free]

See also
tyrosine kinase inhibitor

IGF pathway, IGF axis

phosphoinositol-3-kinase/Akt pathway, Akt pathways, AKT-PIP3 signaling pathway, PI3 kinase pathway, phosphoinositide 3-kinase pathway, phosphatidylinositol-3-kinase/Akt pathway; PI3K-AKT signaling pathway ; PI3K/PTEN/AKT signaling pathway WKP
Members: AKTs, PTEN
Pathology (Dysregulation of the phosphoinositol-3-kinase/Akt pathway)
PTEN germline mutations and dysregulation of the phosphoinositol-3-kinase/Akt pathway Cowden disease Bannayan-Riley-Ruvalcaba syndrome Lhermitte-Duclos (...)

MAPK Pathway; RAS/RAF/MAPK signaling pathway, MAPK signalling pathway, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway, ERK/MAPK pathway, Ras signaling pathway, RAS-ERK signaling pathway, RAS/RAF/MAP/ERK kinase pathway
Members ERK BRAF RASs MAPKs
Pathology
malignant melanoma The MAPK pathway is a key therapeutic target for melanoma as it is activated in most tumors.
Erdheim-Chester disease
Links
Animation of the organisation and (...)