Genetic anomalies

• fractional LOH (fractional allelic loss)
  26 March 2007

  See also
  loss of heterozygosity (LOH)
  allelic imbalance
  References
  Chikwava KR, Hunt JL, Mantha GS, Murphy JE, Jaffe R. Analysis of loss of heterozygosity in single-system and multisystem langerhans’ cell histiocytosis. Pediatr Dev Pathol. 2007 Jan-Feb;10(1):18-24. PMID: #17378622#

• cancers with chromosomal instability
  7 February 2007

  CIN, CCI, mitotic instability

• prognostic genetic parameters
  6 February 2007

  Examples
  Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer. Cancer Res. 2007 Jan 15;67(2):818-26. PMID: #17234794#
  Poor survival outcome in breast cancer (gain at 8q24 and loss at 9q13). (#11438741#)
  Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma (#17210724#)
  Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis (...)

• intratumor heterogeneity
  6 February 2007

  Intratumoral regional variations, intratumoral regional DNA heterogeneity; intratumoral variations; intratumor heterogeneity; tumor heterogeneity; cancer heterogeneity; clonal heterogeneity; intra-tumour heterogeneity; intratumoral heterogeneity
  Open References
  Inter and intratumour heterogeneity: a barrier to individualized medical therapy in renal cell carcinoma? Fisher R, Larkin J, Swanton C. Front Oncol. 2012 May 18;2:49. doi: 10.3389/fonc.2012.00049. PMID: #22655275# (Free) (...)

• SNP cancer genotyping
  4 February 2007

  SNP cancer genotyping, cancer genotyping by SNP array

• minimum overlapping regions
  31 January 2007

  MORs

• minimum overlapping region of amplification
  31 January 2007

  MORA

• minimum overlapping region of deletion
  31 January 2007

  MDR, minimal deleted region, MORD

• anomalies linked to tumoral extension
  31 January 2007

  Examples
  16q24 LOH : vitreous seeding of retinoblastoma (#17210724#)
  See also
  Metastasis
  References
  Gratias S, Rieder H, Ullmann R, Klein-Hitpass L, Schneider S, Boloni R, Kappler M, Lohmann DR. Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Res. 2007 Jan 1;67(1):408-16. PMID: #17210724#

• Oncobase
  23 January 2007

  Oncobase is a database in oncogenetics. It compiles data in cancer cytogenetics and cancer genetics. Tumoral chromosomal anomalies :-) :-) Numerical chromosomal anomalies :-) :-) Monosomies Trisomies Tetrasomies Structural chromosomal anomalies :-) :-) Translocations Insertions Inversions Deletions Isochromosomes :-) CGH anomalies :-) :-) CGH gains CGH losses :-) LOH :-) :-) Cancer loci Cancer genes :-)
  See also
  Tumors (...)

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