Humpath.com - Human pathology

Most recent articles

• von Hansemann histiocytes

  28 September

  von Hansemann histiocyte
  In malakoplakia https://twitter.com/GladellPaner/status/1574732105392672768

• cotyledonoid dissecting leiomyoma

  28 September

  Images
  https://twitter.com/Patholwalker/status/1574869502935695360
  References
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737059/
  https://pubmed.ncbi.nlm.nih.gov/22710314/

• epidermal hyperplastic lesions

  26 September

  focal epidermal hyperplasia : epidermal hyperplastic anomalies
  Types
  focal epidermal hyperplasia : epidermal hyperplastic lesions focal epidermal hyperplasia without cytonuclear atypias pseudoepitheliomatous hyperplasia (PEH) focal epidermal hyperplasia with cytonuclear atypias epidermal cellular dysplasia pre-epitheliomatous keratosis squamous cell carcinoma
  diffuse epidermal hyperplasia (...)

• cyst of the hepatic capsule

  26 September

  cyst of the Glisson capsule
  cyst of the Glisson capsule

• hepatic capsule

  26 September

  Glisson capsule
  Pathology (examples)
  cyst of the Glisson capsule
  non-traumatic pseudocyst of Glisson capsule (#20096426#) cerebrospinal fluid pseudocysts in the peritoneal cavity following ventriculoperitoneal shunt
  pseudolipoma of the Glisson capsule https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582619/

• macrotrabecular massive hepatocellular carcinoma

  26 September

  macrotrabecular-massive HCC PO
  Definition : Subtype of hepatocellular carcinoma with macrotrabecular pattern (≥ 6 - 10 cells thick). Macrotrabecular pattern must represent more than 50% of the tumor.
  Images
  https://twitter.com/emma_furth/status/1574870532452864000
  Synopsis
  hepatocellular carcinoma
  > 50% growth of macrotrabecular pattern (≥ 6 - 10 cells thick)
  Trabeculae observed in cross sections are bordered by a complete rim of CD34 positive endothelial cells in more (...)

• intrahepatic cholangiocarcinoma

  22 September

  iCCA PO
  Definition : Intrahepatic cholangiocarcinoma (iCCA) is a malignant intrahepatic epithelial neoplasm with biliary differentiation, arising in the liver periphery / proximal to the left and right hepatic ducts (WHO 2019)
  Microscopical synopsis
  iCCA consists of infiltrating well formed or cribriform glands in an abundant fibrous stroma (Liver Int 2019;39:7, Surg Pathol Clin 2018;11:403)
  Malignant glands are lined by cells with varying degrees of atypia and pleomorphism (...)

• primary sclerosing cholangitis

  17 September

  PSC WKP PO
  Types
  neonatal sclerosing cholangitis
  auto-immune sclerosing cholangitis
  Microscopy synopsis
  "onion skin" fibrosis around affected medium sized bile ducts; smaller ducts rarely affected (except in small duct primary sclerosing cholangitis), meaning biopsy sampling rarely demonstrates this finding
  progressive atrophy of bile duct epithelium and obliteration of the lumen, leaving a fibrous scar
  ductular reaction and cholestasis may (...)

• well-differentiated hepatocellular anomalies

  7 September

  Types
  focal nodular hyperplasia (FNH) / FNH-like anomalies
  hepatocellular adenoma
  dysplastic nodules
  well-differentiated hepatocellular carcinoma (HCC)
  Differential diagnosis
  Mimics PEComa ( perivascular epithelioid cell neoplasm ) well-differentiated neuroendocrine tumor , especially oncocytic variant
  See also
  hepatocellular anomalies

• hepatocellular anomalies

  7 September

  hepatocellular lesions
  Appearance
  well-differentiated hepatocellular anomalies
  poorly-differentiated hepatocellular anomalies
  undifferentiated hepatocellular anomalies

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