Definition: D2-40 is a monoclonal antibody recognizing podoplanin , a 40 000 kD O-linked sialoglycoprotein located in lymphatic endothelial cells, coded by gene PDPN . This oncofetal antigen is present in fetal germ cells.
Images
A vascular tumor of kaposiform hemangioendothelioma/tufted angioma spectrum in an infant. Note the characteristic podoplanin / PDPN stain
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Expression in normal cells
endothelium of lymphatic channels (...)
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