Gene amplications

Pathology
MDM2 amplification Pulmonary artery intimal sarcoma with MDM2 amplification https://twitter.com/AnneMillsMD/status/827558368923549696
See also
CDK4 amplification
12q13-q15 amplification

Pathology
Amplification of MYC and nuclear expression of MYC is present in secondary angiosarcoma but not atypical vascular lesion (AVL). (#22121953#)
Secondary angiosarcoma and benign but microscopically atypical vascular proliferations (herein referred to as atypical vascular lesion or AVL) are rare consequences of radiation therapy and/or chronic lymphedema most commonly seen in breast cancer patients.
Differentiating angiosarcoma from AVL can be difficult due to overlapping (...)

See also : EGFR
Pathology
Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas. (#22472960#)
References
Concurrence of EGFR amplification and sensitizing mutations indicate a better survival benefit from EGFR-TKI therapy in lung adenocarcinoma patients. Shan L, Wang Z, Guo L, Sun H, Qiu T, Ling Y, Li W, Li L, Liu X, Zheng B, Lu N, Ying J. Lung Cancer. 2015 Jun 19. pii: S0169-5002(15)00293-7. doi:10.1016/j.lungcan.2015.06.008 . PMID: #26141217# (...)

HER-2 amplification,HER2 amplification