In pleura

Open References
Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. Wu D, Hiroshima K, Matsumoto S, Nabeshima K, Yusa T, Ozaki D, Fujino M, Yamakawa H, Nakatani Y, Tada Y, Shimada H, Tagawa M. Am J Clin Pathol. 2013 Jan;139(1):39-46. doi:10.1309/AJCPT94JVWIHBKRD . PMID: #23270897# (free)

DD in pleural pathology

BRMH vs mesothelial neoplasia; benign vs malignant mesothelial proliferations
Even seasoned surgical pathologists who have established expertise in the diagnosis of malignant mesothelioma (MM) can disagree about whether a pleural biopsy represents MM or atypical epithelioid mesothelial hyperplasia (AEMH).
Clinics
When this question arises, the pathologist is well advised to inquire into the clinical features, radiographic findings, and the surgeon’s assessment of the pleura at the time of (...)

Spindle cell tumors of the pleura
Mesothelial cells are pluripotential cells that participate both in surface epithelial cell proliferation and in the remodeling of the deeper layers of the inflamed pleura. It is virtually impossible to distinguish fibroblasts from spindle-shaped mesothelial cells by light microscopy, and immunostains are required to achieve this distinction.
Differential diagnosis
benign mesothelial spindle cell proliferations vs malignant mesothelial spindle cell (...)

Pleomorphic lobular carcinoma
Pleomorphic lobular carcinoma (PLC) is a subtype of infiltrating lobular carcinoma because of its dyscohesiveness, linear infiltration pattern, and lack of membranous E-cadherin staining.
However, it differs from classic lobular carcinoma because of its high-grade cytology and more aggressive clinical behavior.
In breast fine-needle aspiration biopsies, PLC can be confused with invasive ductal carcinoma, particularly the apocrine variant.
Metastatic PLC (...)