References
Systems genetics analysis of cancer susceptibility: from mouse models to humans. Quigley D, Balmain A. Nat Rev Genet. 2009 Sep;10(9):651-7. PMID: #19636343#
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Systems biology
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systems biology in cancer
9 March 2010 -
robustness of signaling networks
14 July 2008Robust biological signaling networks evolved, through gene duplications, from simple, relatively fragile cascades.
Architectural features such as layered configuration, branching and modularity, as well as functional characteristics (e.g., feedback control circuits), enable fail-safe performance in the face of internal and external perturbations.
RTKs pathway
These universal features are exemplified here using the receptor tyrosine kinase (RTKs) family. The RTK module is richly mutated (...) -
systemsX
14 July 2008News:
December 6, 2007: A consortium of Swiss universities will use government and university funds of as much as CHF 400 million ($354 million) over the next four years to create a large-scale systems biology project, called SystemsX.ch. Groups contributing to the research efforts include the Universities of Basel, Berne, Lausanne, Fribourg, Geneva, and Zurich, the Paul Scherrer Institute, Friedrich Miescher Institute, and the Swiss Institute for Bioinformatics, as well as the Federal (...) -
systems engineering
14 July 2008References
Yildirim MA, Vidal M. Systems engineering to systems biology. Mol Syst Biol. 2008;4:185. PMID: #18414486# -
systems biology
18 November 2006Systems medicine
Contemporary views of human disease are based on simple correlation between clinical syndromes and pathological analysis dating from the late 19th century. Although this approach to disease diagnosis, prognosis, and treatment has served the medical establishment and society well for many years, it has serious shortcomings for the modern era of the genomic medicine that stem from its reliance on reductionist principles of experimentation and analysis.
Quantitative, (...)