Pathology
Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. (#22178447#)
References
Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. Greenwood C, Metodieva G, Al-Janabi K, Lausen B, Alldridge L, Leng L, Bucala R, Fernandez N, Metodiev MV. J Proteomics. 2011 Dec 8. PMID: (...)
Home > A. Molecular pathology > CDs
CDs
Clusters of differentiation
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CD74
2 March 2012 -
CD33
15 December 2011Wikipedia
CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
It binds sialic acids, therefore is a member of the SIGLEC family of lectins.
The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor (...) -
CD26
20 July 2010DPP4
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CD31
28 April 2010platelet endothelial cell adhesion molecule (PECAM1, OMIM 173445), PECA1, GPIIA, endoCAM, CD31/EndoCAM (Entrez Gene: platelet/endothelial cell adhesion molecule) PO
See PECAM1
References
CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. Westerhoff M, Tretiakova M, Hovan L, Miller J, Noffsinger A, Hart J. Am J Surg Pathol. 2010 Apr;34(4):494-501. PMID: (...) -
CD61
28 April 2010References
CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. Westerhoff M, Tretiakova M, Hovan L, Miller J, Noffsinger A, Hart J. Am J Surg Pathol. 2010 Apr;34(4):494-501. PMID: #20351488# -
CD163
8 January 2010WKP PO
CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene.
CD163 has been shown to interact with CSNK2B.
Hp protects hemoglobin (Hb) when oxidatively challenged with H(2)O(2) preserving CD163-mediated Hb clearance under oxidative stress conditions.
During bacterial infection, CD163 on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation.
CD163 has at least two distinct functions: the clearance of hemoglobin (...) -
CD103
4 January 2010See also ITGAE.
Integrin, alpha E (ITGAE) also known as CD103 (Cluster of Differentiation 103) is an integrin.
CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name.
The αEβ7 complex is often referred to as "CD103" though this appellation strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).
Tissue Distribution
CD103 is expressed widely on intraepithelial (...) -
CD23
28 October 2009HUGO:FCER2 PO WP
CD23 (FCER2 ) is a key molecule for B-cell activation and growth. It is a low affinity IgE receptor (Fc fragment of IgE receptor, FCERs). CD23 is a type C lectin that can be secreted.
After physiologic germinal cell development, the follicular dendritic cell meshwork expands and follicular dendritic cells in the light zone of the germinal center become CD23 positive. CD23 acts as a B cell growth and activation factor, promoting differentiation into plasma cells. CD23 (...) -
CD138
21 October 2009Aka heparan sulfate proteoglycan, syndecan-1
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CD123
21 October 2009References
CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: diagnostic and pathogenetic implications. Kutzner H, Kerl H, Pfaltz MC, Kempf W. Am J Surg Pathol. 2009 Sep;33(9):1307-13. PMID: #19718787#