CDs

• CD19
  29 April 2020

  WKP
  Definition : B-lymphocyte antigen CD19, also known as CD19 molecule (Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene CD19.
  In humans, CD19 is expressed in all B lineage cells, except for plasma cells, and in follicular dendritic cells.
  CD19 plays two major roles in human B cells. It acts as an adaptor protein to recruit cytoplasmic signaling proteins to the (...)

• CD35
  2 May 2017

  See : CR1

• CD37
  27 October 2016

  Pathology
  Assessment of CD37 B-cell antigen and cell-of-origin significantly improves risk prediction in diffuse large B-cell lymphoma (DLNCL). doi:10.1182/blood-2016-05-715094. CD37 positivity predicts significantly better survival in DLBCL treated with R-CHOP, predominating other prognostic factors in GCB-DLBCL. CD37 loss is a potent risk factor for R-CHOP resistance in both GCB- and (...)

• CD24
  21 September 2016

  Pathology
  CD24 was shown to be overexpressed in high-grade serous carcinoma (HGSC) effusions compared to malignant mesothelioma (MM) in gene expression array analysis.
  CD24 is highly useful in differentiating high-grade serous carcinoma from benign and malignant mesothelial cells. http://dx.doi.org/10.1016/j.humpath.2016.08.005 In a study, Reactive mesothelial cells were CD24-negative in all carcinoma specimens. The overexpression of CD24 in ovarian carcinoma effusions compared to (...)

• CD8
  4 July 2016

  Diagnostis use - Examples
  pancreatic tail : splenule. CD8 highlights splenic endothelial cells https://twitter.com/marthabpitman/status/745600732301303808
  See also
  CDs

• CD109
  14 September 2015

  WKP
  CD109 is a co-receptor of TGF-β1 and suppresses TGF-β signaling.
  CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002).
  In addition, the platelet-specific Gov antigen system, implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin (...)

• CD117
  19 August 2014

  WKP PO
  Voir KIT
  Positive staining in normal cells
  Interstitial cells of Cajal
  hematopoietic progenitor cells
  melanocytes
  embryonic/fetal brain
  endothelium
  gonads
  mast cells
  breast epithelium
  germ cells
  Positive staining in tumors
  AML
  angiomyolipoma
  angiosarcomas
  clear cell sarcoma
  CML
  epithelioid sarcoma
  Ewing sarcoma
  gastrointestinal autonomic tumor (GANT)
  gastrointestinal stromal tumor (GIST)
  granulocytic sarcoma
  Hodgkin lymphoma (some Reed-Sternberg cells) (...)

• CD279
  24 July 2013

  PDCD1; PD-1
  See: PDCD1

• CD43
  10 August 2012

  References
  Use of the JL1 Epitope, Which Encompasses the Nonglycosylation Site of CD43, as a Marker of Immature/Neoplastic Langerhans Cells. Park HJ, Jeon YK, Lee AH, Oh YH, Park SH, Jung KC. Am J Surg Pathol. 2012 Aug;36(8):1150-7. PMID: #22790855#

• CD14
  10 April 2012

  See also
  CDs

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