miRNAs

• miR-34a
  11 October 2011

  References
  The MYCN oncogene is a direct target of miR-34a. Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT, Tsang P, Zhang Q, Thiele CJ, Slack A, Shohet J, Khan J. Oncogene. 2008 Sep 4;27(39):5204-13. PMID: #18504438# [Free]

• miR-205
  8 February 2011

  References
  miR-205 Expression Levels in Nonsmall Cell Lung CancerDo Not Always Distinguish Adenocarcinomas From Squamous Cell Carcinomas. Vescovo VD, Cantaloni C, Cucino A, Girlando S, Silvestri M, Bragantini E, Fasanella S, Cuorvo LV, Palma PD, Rossi G, Papotti M, Pelosi G, Graziano P, Cavazza A, Denti MA, Barbareschi M. Am J Surg Pathol. 2011 Feb;35(2):268-275. PMID: #21263248#

• miRTRAP
  12 May 2010

  MicroRNAs (miRNAs) have been broadly implicated in animal development and disease.
  A novel computational strategy for the systematic, whole-genome identification of miRs from high throughput sequencing information, have been developed.
  This method, miRTRAP, incorporates the mechanisms of miR biogenesis and includes additional criteria regarding the prevalence and quality of small RNAs arising from the antisense strand and neighboring loci.
  This program was applied to the simple chordate (...)

• miR-17-92
  22 December 2009

  miR-17-92 Cluster

• miRNAs in cancer
  23 October 2009

  microRNAs in tumors, miRNAs in tumors; miRNAs as tumoral biomarkers
  MicroRNAs (miRNAs) are small RNAs of 18-24 nucleotides in length that are involved in the regulation of gene expression and hence a variety of biological processes through post-transcriptional RNA interference-based mechanisms. Matured miRNAs interact and inhibit target mRNAs and result in translational repression or mRNA cleavage.
  The classic view of molecular oncology indicates that cancer is a genetic disease (...)

• let-7 miRNAs
  29 September 2008

  The let-7 miRNA was originally discovered in the nematode Caenorhabditis elegans, where it regulates cell proliferation and differentiation, but subsequent work has shown that both its sequence and its function are highly conserved in mammals.
  Results have now linked decreased let-7 expression to increased tumorigenicity and poor patient prognosis.
  Moreover, during normal development, accumulation of let-7 can be prevented by LIN28, a promoter of pluripotency. Based on these findings, we (...)

• MIR122
  6 May 2008

  miR-122

• MIR34
  6 January 2008

  miR-34s

• MIR181
  28 November 2007

  miR-181

• MIR29
  28 November 2007

  miR-29

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