miRNAs

• miR-486
  12 October 2013

  miRNA-486; micro RNA 486
  Pathology
  microRNA 486 found to be potent lung cancer tumor suppressor, linked with p53 pathway. http://medicalxpress.com/news/2013-09-microrna-molecule-potent-tumor-suppressor-lung.html

• miR-200
  12 October 2013

  miR200
  Pathology
  Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. (#24393345#)
  therapeutic potential of mir-200 to ablate #angiogenesis by targeting cancer pathways.
  Open references
  Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200. Kobayashi M, Salomon C, Tapia J, Illanes SE, Mitchell MD, Rice GE. J Transl Med. 2014 Jan 6;12(1):4. PMID: #24393345# (...)

• mir-21
  12 October 2013

  Pathology
  MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.. many glioblastoma cell lines overexpress mir-21, which has been shown to block #apoptosis genes http://ow.ly/pvjtt www.ncbi.nlm.nih.gov/pubmed/16024602

• miRNA-874
  12 October 2013

  microRNA-874
  Pathology
  Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer. Divya Kesanakurti et al. http://www.sciencedirect.com/science/article/pii/S0006291X13006116

• miRNA-let-7d
  2 July 2012

  microRNA-let-7d
  References
  Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples. Nuovo GJ, Garofalo M, Valeri N, Roulstone V, Volinia S, Cohn DE, Phelps M, Harrington KJ, Vile R, Melcher A, Galanis E, Sehl S, Adair R, Scott K, Rose A, Toogood G, Coffey MC. Mod Pathol. 2012 Jun 15. PMID: #22699519#

• mIR-222
  4 January 2012

  MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors.
  A study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition.
  Pathology
  Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors.
  References (...)

• miR-221
  4 January 2012

  MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors.
  A study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition.
  Pathology
  Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors.
  References (...)

• hsa-miR-9
  4 January 2012

  References
  Real-time PCR-based analysis of the human bile microRNAome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer. Shigehara K, Yokomuro S, Ishibashi O, Mizuguchi Y, Arima Y, Kawahigashi Y, Kanda T, Akagi I, Tajiri T, Yoshida H, Takizawa T, Uchida E. PLoS One. 2011;6(8):e23584. doi:10.1371/journal.pone.0023584 . PMID: #21858175# [Free]
  Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in (...)

• miRNA-125b
  28 November 2011

  microRNA-125b

• miR-184
  14 November 2011

  MicroRNAs (miRNAs) bind to complementary sequences within the 3’ untranslated region (UTR) of mRNAs from hundreds of target genes, leading either to mRNA degradation or suppression of translation.
  A mutation in the seed region of miR-184 (MIR184) is responsible for familial severe keratoconus combined with early-onset anterior polar cataract by deep sequencing of a linkage region known to contain the mutation.
  The mutant form fails to compete with miR-205 (MIR205) for overlapping target (...)

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