Digestive system

• digestive mucosal infiltrate
  7 December 2011

  Digital case
  HPC:327 : colonic mucosal infiltrate in lymphocytic colitis
  HPC:328 : gastric mucosal infiltrate in lymphocytic gastritis
  Types
  digestive mucosal lymphocytic infiltrate
  digestive mucosal plasmocytic infiltrate
  digestive mucosal eosinophilic infiltrate
  digestive mucosal histiocytic infiltrate
  Etiology (Example)
  lymphocytic colitis

• digestive B-cell lymphomas
  30 November 2011

  Digital case
  HPC:296 : Colonic MALT lymphoma
  HPC:297 : gastric diffuse large B-cell lymphoma (mucosal biopsies)
  HPC:319 : Gastric MALT lymphoma / Gastric marginal zone lymphoma (fundic mucosal biopsies)
  HPC:330 : Rectal marginal zone B-cell lymphoma (Rectal MALT lymphoma)
  See also
  B-cell lymphomas
  digestive lymphomas

• digestive marginal zone B-cell lymphoma
  29 November 2011

  digestive MALT lymphoma, digestive MZBCL, marginal zone B-cell lymphoma of the digestive system
  Digital cases
  HPC:296 : Colonic MALT lymphoma
  HPC:298 : Residual disease of digestive MALT lymphoma after treatment
  HPC:304 : Gastric MALT lymphoma / Gastric marginal zone lymphoma (mucosal biopsies)
  HPC:313 : Minimal residual disease after treated gastric MALT lymphoma
  HPC:319 : Gastric MALT lymphoma / Gastric marginal zone lymphoma (fundic mucosal biopsies)
  Images (...)

• hereditary non-syndromic colorectal cancer
  29 November 2011

  References
  Deciphering the genetics of hereditary non-syndromic colorectal cancer. Papaemmanuil E, Carvajal-Carmona L, Sellick GS, Kemp Z, Webb E, Spain S, Sullivan K, Barclay E, Lubbe S, Jaeger E, Vijayakrishnan J, Broderick P, Gorman M, Martin L, Lucassen A, Bishop DT, Evans DG, Maher ER, Steinke V, Rahner N, Schackert HK, Goecke TO, Holinski-Feder E, Propping P, Van Wezel T, Wijnen J, Cazier JB, Thomas H, Houlston RS, Tomlinson I; CORGI Consortium. Eur J Hum Genet. 2008 (...)

• MUTYH-associated polyposis carcinomas
  29 November 2011

  Genetic instability is known to drive colorectal carcinogenesis. Generally, a distinction is made between two types of genetic instability: chromosomal instability (CIN) and microsatellite instability (MIN or MSI). Most CIN tumours are aneuploid, whereas MSI tumours are considered near-diploid.
  However, for MUTYH-associated polyposis (MAP) the genetic instability involved in the carcinogenesis remains unclear, as near-diploid adenomas, aneuploid adenomas and near-diploid carcinomas have (...)

• immature digestive ganglion cells
  29 November 2011

  Immature enteric neurons

• digestive ganglion cells
  29 November 2011

  Localization
  submucosal ganglion cells
  myenteric ganglion cells
  Pathology: anomalies of digestive ganglion cells
  absence
  hyperplasia
  References
  Morphological alterations of the enteric nervous system in young male patients with rectal prolapse. Zorenkov D, Otto S, Böttner M, Hedderich J, Vollrath O, Ritz JP, Buhr H, Wedel T. Int J Colorectal Dis. 2011 Nov;26(11):1483-91. PMID: #21800050#
  Counting myenteric ganglion cells in histologic sections: an empirical approach. (...)

• submucosal hyperganglionosis
  29 November 2011

  See also
  intestinal neuronal dysplasia
  References
  Morphological alterations of the enteric nervous system in young male patients with rectal prolapse. Zorenkov D, Otto S, Böttner M, Hedderich J, Vollrath O, Ritz JP, Buhr H, Wedel T. Int J Colorectal Dis. 2011 Nov;26(11):1483-91. PMID: #21800050#
  Counting myenteric ganglion cells in histologic sections: an empirical approach. Swaminathan M, Kapur RP. Hum Pathol. 2010 Mar 24. PMID: (...)

• myenteric hyperganglionosis
  29 November 2011

  Etiology:
  diffuse intestinal myenteric hyperganglionosis The diffuse intestinal myenteric hyperganglionosis is characterized by hyperplastic ganglia throughout the large and small intestine, associated with severe constipation. The hyperganglionosis is associated with immunohistochemical findings of intact expression of the neuropeptides controlling the peristaltic reflex, through lower expression of calcitonin-gene related peptide. (#7507990#)
  See also
  neuronal intestinal dysplasia (...)

• digestive ganglioneuromatosis
  29 November 2011

  PTEN
  Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a phosphatase that is critical for controlling cell growth, proliferation and cell death.
  A recent study of Pten knockout mice showed evidence of ganglioneuromatosis in the ENS suggesting a role for this protein in ENS development.
  Ganglioneuromatosis patients have also been shown to have a decreased level of Pten expression in the colon.
  There is a marked reduction of Pten expression in the myenteric and submucous (...)

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