See also
6p25.3
Open references
Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders. Sciallis AP, Law ME, Inwards DJ, McClure RF, Macon WR, Kurtin PJ, Dogan A, Feldman AL. Mod Pathol. 2012 Jul;25(7):983-92. doi:10.1038/modpathol.2012.38. PMID: #22388754#
Paywall References
Primary Cutaneous Anaplastic Large-Cell Lymphoma With 6p25.3 Rearrangement in a Cardiac (...)
Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral chromosomal rearrangements
Tumoral chromosomal rearrangements
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6p25.3 rearrangement
6 January 2017 -
8p21 rearrangement
8 December 20118p21 rearrangements
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3q27 rearrangement
11 October 20113q27 aberrations, 3q27 rearrangements
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1q rearrangements
3 May 2011Tumors
multiple myeloma (AGCOH) -
Chr.18 rearrangements
1 February 2008Leukemias
t(1;18)(q25;q23) 1q25 and 18q23 (no genes)
t(1;18)(q10;q10) 1q10 and 18q10 (no genes)
t(2;18)(p11;q21) (IGKC/BCL2) (IGKC at 2p11/BCL2 at 18q21)
t(3;18)(q26;q11) EVI1 at 3q26.2 and 18q11
der(9;18)(p10;q10) 9p10 and 18q10
t(11;18)(q21;q21) BIRC3 at 11q21 and MALT1 at 18q21
t(14;18)(q32;q21) IGH at 14q32 and BCL2 at 18q21
t(18;21)(q21;q22) 18q21 and AML1 at 21q22
t(18;22)(q21;q11) BCL2 at 18q21 and IGL at 22q11
Solid tumors
t(X;18)(p11.2;q11.2) (...) -
1q12-22 rearrangements
10 September 2007Types
1q12-22 breaks
dup(1)(q12-21q32)
trp(1)(q12q32)
Pathology
Abnormalities of chromosome arm 1q have frequently been reported in B-cell lymphomas and correlated with poor outcome.
Five genes mapped to this region (BCL9, MUC1, FCGR2B, IRTA1, and RTA2) have been shown to be deregulated by juxtaposition with the IG genes.
Other anomalies of the 1q21-22 region are not involved in translocations with the IG genes.
Unbalanced translocations resulting in trisomy 1q and involving (...) -
3q26 rearrangements
1 September 2007Target genes
EVI1
References
Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, Miller C, Saunders EK, White DJ, Will AM, Eden T, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tonnies H. Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosomes Cancer. 2007 Apr;46(4):359-72. PMID: (...) -
Xp11.2 rearrangements
6 August 2007See also
TFE3
References
Melanotic Xp11.2 neoplasm of the ovary: report of a unique case. Legallo RD, Stelow EB, Sukov WR, Duska LR, Alisanski SB, Folpe AL. Am J Surg Pathol. 2012 Sep;36(9):1410-4. PMID: #22895274#
Rakheja D, Kapur P, Tomlinson GE, Margraf LR. Pediatric renal cell carcinomas with Xp11.2 rearrangements are immunoreactive for hMLH1 and hMSH2 proteins. Pediatr Dev Pathol. 2005 Nov-Dec;8(6):615-20. PMID: (...) -
1q42 rearrangements
18 May 2007Tumors
uterine leiomyoma (#12419594#)
References
Dal Cin P, Morton CC. 1q42 approximately q44 is rarely cytogenetically involved in sporadic uterine leiomyomata. Cancer Genet Cytogenet. 2002 Oct 1;138(1):92-3. PMID: #12419594# -
12p13 rearrangements
19 March 2007Synopsis
ETV6 rearrangements in Leukemias t(1;12)(q25;p13) t(1;12)(p36;p13) t(2;12)(q31;p13) t(3;12)(q26;p13) t(4;12)(q11-q21;p13) t(4;12)(p16;p13) t(5;12)(q33;p13) t(6;12)(p21;p13) in lymphoid malignancies t(7;12)(q36;p13) t(7;12)(p12;q13) t(7;12)(q34;p13) t(8;12)(q22;q13) t(9;12)(p24;p13) (SYK/ETV6) dic(9;12)(p13;p13) t(9;12)(q22;p12) t(9;12)(q34;p13) t(11;12)(p15;p13) t(11;12)(q23;q13) (/HMGA2) t(11;12)(q23;q13) (MLL/CIP29) t(12;12)(p13;q13) t(12;13)(p12;q12-14) t(12;14)(p13;q11) (...)
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