CGH gains

• 17q24.3-q25.3 gain
  20 January 2012

  Pathology
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. (#21652146#)
  References
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. Pezzolo A, Coco S, Raso A, Parodi F, Pistorio A, Valdora F, Capra V, Zollo M, Aschero S, Basso E, Cama A, Nozza P, Gambini C, Cinalli G, Garrè ML, Iolascon A, Pistoia V, Tonini GP. Cancer Lett. (...)

• 7q34-q36.3 gain
  20 January 2012

  Pathology
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. (#21652146#)
  References
  Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma. Pezzolo A, Coco S, Raso A, Parodi F, Pistorio A, Valdora F, Capra V, Zollo M, Aschero S, Basso E, Cama A, Nozza P, Gambini C, Cinalli G, Garrè ML, Iolascon A, Pistoia V, Tonini GP. Cancer Lett. (...)

• 20q gain
  28 November 2011

  Pathology
  Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas. (#21445971#)
  References
  Increased frequency of 20q gain and copy-neutral loss of heterozygosity in mismatch repair proficient familial colorectal carcinomas. Middeldorp A, van Eijk R, Oosting J, Forte GI, van Puijenbroek M, van Nieuwenhuizen M, Corver WE, Ruano D, Caldes T, Wijnen J, Morreau H, van Wezel T. Int J Cancer. 2011 Mar 28. PMID: (...)

• 9qter gain
  9 September 2010

  9q33-34 gain

• 1q gain
  9 September 2010

  Gain of 1q and loss of 22 are the most common changes detected by comparative genomic hybridisation in paediatric ependymoma. (Genes Chromosomes Cancer 32:59–66)
  Gains on 1q and epidermal growth factor receptor overexpression are independent prognostic markers in intracranial ependymoma. (Clin Cancer Res 12:2070–2079)
  References
  Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B, Lichter P (2006) Identification of gains on 1q and epidermal growth factor receptor (...)

• 2p24 gain
  21 April 2010

  Target genes
  MYCN
  See also
  MYCN amplification
  References
  2p24 Gain Region Harboring MYCN Gene Compared with MYCN Amplified and Nonamplified Neuroblastoma. Biological and Clinical Characteristics. Jeison M, Ash S, Halevy-Berko G, Mardoukh J, Luria D, Avigad S, Feinberg-Gorenshtein G, Goshen Y, Hertzel G, Kapelushnik J, Ben Barak A, Attias D, Steinberg R, Stein J, Stark B, Yaniv I. Am J Pathol. 2010 Apr 15. PMID: (...)

• 5p15.33 gain
  19 May 2008

  Tumors
  non-small cell lung cancers (#18328944#) pulmonary epidermoid carcinoma pulmonary adenocarcinoma
  Target genes
  TERT
  SLC6A19
  SLC6A18
  References
  Kang JU, Koo SH, Kwon KC, Park JW, Kim JM. Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Cancer Genet Cytogenet. 2008 Apr 1;182(1):1-11. PMID: (...)

• 7q22.1 gain
  17 May 2008

  Tumors
  esophageal adenocarcinoma
  Target genes
  MUC3
  See also
  7q gain

• 15q gain
  19 July 2007

  Target genes
  IGFR1 overexpression
  References
  Natrajan R, Little SE, Sodha N, Reis-Filho JS, Mackay A, Fenwick K, Ashworth A, Perlman EJ, Dome JS, Grundy PE, Pritchard-Jones K, Jones C. Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms’ tumour.
  J Pathol. 2007 Jan;211(1):52-9. PMID: #17103382#
  Natrajan R, Reis-Filho JS, Little SE, Messahel B, Brundler MA, Dome JS, Grundy PE, Vujanic GM, Pritchard-Jones K, Jones C. Blastemal expression of type (...)

• 8q gain
  26 June 2007

  Tumors
  gastrointestinal stromal tumor (GIST) (#17330260#)
  Driver genes
  MYC

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