WKP
P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.
The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria.
The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina.
The P2X7 receptor also serves as a pattern (...)
Home > A. Molecular pathology
A. Molecular pathology
-
P2X7R
26 April 2017 -
B3GAT2
25 April 2017Open references
Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett’s Esophagus. Yu M, O’Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong CJ, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM. Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1890-7. doi:10.1158/1055-9965.EPI-15-0370.
PMID: #26545406# (...) -
ZNF793
25 April 2017Open references
Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett’s Esophagus.
Yu M, O’Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong CJ, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM.
Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1890-7. doi:10.1158/1055-9965.EPI-15-0370.
PMID: (...) -
proteostasis
21 April 2017The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases.
Proteome integrity is maintained by the proteostasis network (PN), which consists of interconnected systems that regulate protein synthesis, folding, transport, and degradation in every cell.
The functionality of this network declines during aging, thus compounding the (...) -
rare somatic variants
21 April 2017Genome-wide sequencing studies have shown that individual malignancies contain many mutations that range from those commonly found in tumor genomes to rare somatic variants present only in a small fraction of lesions.
Such rare somatic variants dominate the landscape of genomic mutations in cancer, yet efforts to correlate somatic mutations found in one or few individuals with functional roles have been largely unsuccessful.
Traditional methods for identifying somatic variants that drive (...) -
protein domains
21 April 2017Examples
protein interaction domains
Open References
Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. 2017. doi:10.1371/journal.pcbi.1005428. -
retroelements
21 April 2017References.
Retroelement-guided protein diversification abounds in vast lineages of Bacteria and Archaea. 2017. http://www.nature.com/articles/nmicrobiol201745 http://www.nature.com/articles/nmicrobiol201745.epdf -
ADIPOR2
25 March 2017|WKP|
Definition: Adiponectin is a protein which in humans is encoded by the ADIPOQ gene. It is involved in regulating glucose levels as well as fatty acid breakdown.
See also
ADIPOR1
ADIPOR2
Paywall references
Structural biology: Receptors grease the metabolic wheels. doi:10.1038/nature21900. -
ADIPOQ
25 March 2017adiponectin, C1Q and collagen domain containing
|WKP|
Definition: Adiponectin is a protein which in humans is encoded by the ADIPOQ gene. It is involved in regulating glucose levels as well as fatty acid breakdown.
See also
ADIPOR1
ADIPOR2
Paywall references
Structural biology: Receptors grease the metabolic wheels. doi:10.1038/nature21900. -
CREBs
16 March 2017Examples
ATF1
CREB1
0 | ... | 40 | 50 | 60 | 70 | 80 | 90 | 100 | 110 | 120 | ... | 4280