A. Molecular pathology

GIT2
4 December 2017

Pathology
BRAF-GIT2 fusion gene in pilocytic astrocytoma
Open references
A novel GIT2-BRAF fusion in pilocytic astrocytoma.
Helgager J, Lidov HG, Mahadevan NR, Kieran MW, Ligon KL, Alexandrescu S.
Diagn Pathol. 2017 Nov 15;12(1):82. doi:10.1186/s13000-017-0669-5.
PMID: #29141672# Free
mutant TP53
20 November 2017

See also : TP53
References
More targets, more pathways and more clues for mutant p53.
Garritano S, Inga A, Gemignani F, Landi S.
Oncogenesis. 2013 Jul 1;2:e54. doi:10.1038/oncsis.2013.15.
PMID: #23817466# Free
bHLH-PAS
20 November 2017

bHLH-PAS
See also
ARNT2
ARNT2
20 November 2017

WKP
Definition: Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors.
The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.
Under (...)
β-Adrenergic receptor
29 August 2017

β-Adrenergic receptor expression in vascular tumors (#22743651#)
Propranolol has recently emerged as an effective therapy for infantile hemangiomas causing regression.
The β-adrenergic receptor (AR) antagonist is thought to cause vasoconstriction by its effect on nitric oxide, block angiogenesis by its effect on vascular endothelial growth factor (VEGF), and induce apoptosis.
The expression of β2-AR (B2-AR) and its phosphorylated form (B2-ARP) have been identified in a case of infantile (...)
ADAR2
20 August 2017

Pathology
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis. ADAR2 is overexpressed in EC and that the increase in expression positively correlates with the aggressiveness of the tumor. Furthermore, silencing of ADAR2 in three EC cell lines resulted in a decreased proliferation rate, increased apoptosis, and reduced migration capabilities in vitro. ADAR2 functions as an oncogene in endometrial carcinogenesis and could be a (...)
NADPH
8 August 2017

WKP
See also : NADH
Definition: Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2’ position of the ribose ring that carries the adenine moiety.
The major source of NADPH in (...)
SUZ12
25 July 2017

WKP
Images
LOW-GRADE ENDOMETRIAL STROMAL SARCOMA. NGS: JAZF1-SUZ12. NB: permeation of myometrium; whorls of bland spindle cells; prominent arterioles. https://twitter.com/histiocytosisX/status/888838034518671360
PDCD1LG2
19 June 2017

PD-L2; B7-DC; PDL2 ; CD273 WKP
PD-L2 (or Programmed cell death 1 ligand 2) is a protein that in humans is encoded by the PDCD1LG2 gene. PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).
See also
immune checkpois
PD-1 and PD-L1
Links
http://ecancer.org/news/11795-tumour-pd-l2-expression-may-predict-patient-response-to-anti-pd-1-immunotherapy.php
Open references
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation.
Bardhan K, (...)
SATB2
15 June 2017

WKP
Definition: Special AT-rich sequence-binding protein 2 (SATB2) also known as DNA-binding protein SATB2 is a protein that in humans is encoded by the SATB2 gene.
SATB2 is a DNA-binding protein that specifically binds nuclear matrix attachment regions and is involved in transcriptional regulation and chromatin remodeling. *
IHC
neuroendocrine tumors SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors. (#26261600#)
digestive tumors (...)

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A. Molecular pathology

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