A. Molecular pathology

• advanced glycation end-products
  7 May 2018

  AGEs; advanced glycation end-product
  Definition: Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars, or glycation.
  Pathology
  Advanced glycation end products (AGEs) can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer’s disease.
  See also (...)

• ACTA2
  19 March 2018

  WKP
  Definition: Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.
  Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms (ACTAs ) which have been identified.
  Actins (ACTs ) are highly conserved proteins that are involved in cell motility, structure and integrity.
  Alpha actins (ACTAs ) are a (...)

• carbon-carbon bond
  14 March 2018

  References
  Molecular-decoration technique offers boost to medicinal chemists. 2019 https://www.nature.com/articles/d41586-019-00767-w

• biological organization
  24 February 2018

  biological organisation
  |WKP|
  Definition : Biological organization is the hierarchy of complex biological structures and biologial systems.
  This traditional hierarchy extends from atoms to biospheres. The higher levels of this scheme are often referred to as an ecological organisation concept, or as the field, hierarchical ecology.
  Each level in the hierarchy represents an increase in organisational complexity , with each "object" being primarily composed of the previous level’s basic (...)

• REP1
  27 January 2018

  WKP
  Definition: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.
  This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction.
  Rab GTPases need to be geranylgeranyled on either one or two cysteine (...)

• farnesylation
  27 January 2018

  Definition: Farnesylation is a type of prenylation , a post-translational modification of proteins by which an isoprenyl group is added to a cysteine residue.
  It is an important process to mediate protein–protein interactions and protein–membrane interactions.
  Protein farnesylation involves the transfer of a farnesyl moiety to C-terminal cysteine(s) of the target protein. There are enzymes that carry out this type of prenylation as farnesyl transferase.
  Farnesyltransferase and (...)

• molecular events
  27 January 2018

  biochemical events
  Definition: A molecular event is a biochemical reaction changing a biochemical component.
  Examples
  post-traductional modifications
  protein phosphorylation
  protein glycosylation
  protein farnesylation
  myristoylation
  palmitoylation
  nucleic acid methylation
  Signal transduction
  Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalysed (...)

• OCLN
  3 January 2018

  WKP
  Definition: Occludin is a protein that in humans is encoded by the OCLN gene. Occludin is a 65-kDa (522-amino acid polypeptide -human) integral plasma-membrane protein located at the tight junctions, described for the first time in 1993 by Shoichiro Tsukita.
  Together with the Claudin group of proteins, it is the main component of the tight junctions.
  Pathology
  Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse (...)

• GIT2
  4 December 2017

  Pathology
  BRAF-GIT2 fusion gene in pilocytic astrocytoma
  Open references
  A novel GIT2-BRAF fusion in pilocytic astrocytoma.
  Helgager J, Lidov HG, Mahadevan NR, Kieran MW, Ligon KL, Alexandrescu S.
  Diagn Pathol. 2017 Nov 15;12(1):82. doi:10.1186/s13000-017-0669-5.
  PMID: #29141672# Free

• mutant TP53
  20 November 2017

  See also : TP53
  References
  More targets, more pathways and more clues for mutant p53.
  Garritano S, Inga A, Gemignani F, Landi S.
  Oncogenesis. 2013 Jul 1;2:e54. doi:10.1038/oncsis.2013.15.
  PMID: #23817466# Free

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