A. Molecular pathology

• 17beta-estradiol
  3 July 2003
• DMD
  3 July 2003

  dystrophin

• ANK2
  1 July 2003

  ankyrin-B, ankyrin-2

• ALK
  19 June 2003

  Locus: 2p23. AGCOH OMIM
  Cytogenetics
  t(2;17)(p23;q23)
  Pathology
  ALK rearrangements - ALK fusion
  Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types.
  In tumorigenesis, the ALK gene at 2p23 is known to be fused to NPM, TPM3, TPM4, TFG, ATIC, CLTC, MSN, and ALO17.
  ALK-ATIC by inv(2)(p23q35) in IMF (#12939746#) (...)

• CD44
  17 June 2003

  Definition: CD44 is a well characterized cellular adhesion molecule involved in several human malignancies. It is encoded by a gene located at 11p12-13.
  Functions
  CD44 binds hyaluronan. Mucin-like glycoproteins, such as heparan sulfate, serve as ligands for the leukocyte adhesion molecule called CD44. These glycoproteins are found in the extracellular matrix and on cell surfaces.
  CD44 is expressed by lymphoid cells, and is involved in the extravasation of lymphoid cells, it does not (...)

• molecular psychiatry
  16 June 2003

  References
  Gray L, Hannan AJ. Dissecting cause and effect in the pathogenesis of psychiatric disorders: genes, environment and behaviour. Curr Mol Med. 2007 Aug;7(5):470-8. PMID: #17691962#
  Lehrmann E, Hyde TM, Vawter MP, Becker KG, Kleinman JE, Freed WJ. The use of microarrays to characterize neuropsychiatric disorders: postmortem studies of substance abuse and schizophrenia. Curr Mol Med. 2003 Aug;3(5):437-46. PMID: #12942997#
  Voshol H, Glucksman MJ, van Oostrum J. Proteomics in the (...)

• NOTCH3
  11 June 2003

  Notch3

• NOTCH1
  11 June 2003

  Notch1

• Notch signaling pathway
  11 June 2003

  Notch signalling pathway

• signaling pathways
  11 June 2003

  signaling network, signalling pathways, regulatory pathways, molecular pathways, signaling networks
  Main signaling pathways
  ALK1 pathaway
  MAPK signaling pathways (ras/MAPK pathways)
  Ras/MEK/ERK signaling pathway (RAS-ERK signaling pathway)
  JNK/MAPK signaling pathway
  Notch signaling pathway
  WNT signaling pathway (catenins/APC signaling pathway)
  PI3K/PTEN/AKT signaling pathway (phosphoinositol-3-kinase/Akt signaling pathway)
  TSC/FRAP1 pathway (TSC/mTOR pathway)
  NF-kappaB (...)

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