References
Molecular-decoration technique offers boost to medicinal chemists. 2019 https://www.nature.com/articles/d41586-019-00767-w
Home > A. Molecular pathology
A. Molecular pathology
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carbon-carbon bond
14 March 2018 -
biological organization
24 February 2018biological organisation
|WKP|
Definition : Biological organization is the hierarchy of complex biological structures and biologial systems.
This traditional hierarchy extends from atoms to biospheres. The higher levels of this scheme are often referred to as an ecological organisation concept, or as the field, hierarchical ecology.
Each level in the hierarchy represents an increase in organisational complexity , with each "object" being primarily composed of the previous level’s basic (...) -
REP1
27 January 2018WKP
Definition: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction.
Rab GTPases need to be geranylgeranyled on either one or two cysteine (...) -
farnesylation
27 January 2018Definition: Farnesylation is a type of prenylation , a post-translational modification of proteins by which an isoprenyl group is added to a cysteine residue.
It is an important process to mediate protein–protein interactions and protein–membrane interactions.
Protein farnesylation involves the transfer of a farnesyl moiety to C-terminal cysteine(s) of the target protein. There are enzymes that carry out this type of prenylation as farnesyl transferase.
Farnesyltransferase and (...) -
molecular events
27 January 2018biochemical events
Definition: A molecular event is a biochemical reaction changing a biochemical component.
Examples
post-traductional modifications
protein phosphorylation
protein glycosylation
protein farnesylation
myristoylation
palmitoylation
nucleic acid methylation
Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalysed (...) -
OCLN
3 January 2018WKP
Definition: Occludin is a protein that in humans is encoded by the OCLN gene. Occludin is a 65-kDa (522-amino acid polypeptide -human) integral plasma-membrane protein located at the tight junctions, described for the first time in 1993 by Shoichiro Tsukita.
Together with the Claudin group of proteins, it is the main component of the tight junctions.
Pathology
Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse (...) -
GIT2
4 December 2017Pathology
BRAF-GIT2 fusion gene in pilocytic astrocytoma
Open references
A novel GIT2-BRAF fusion in pilocytic astrocytoma.
Helgager J, Lidov HG, Mahadevan NR, Kieran MW, Ligon KL, Alexandrescu S.
Diagn Pathol. 2017 Nov 15;12(1):82. doi:10.1186/s13000-017-0669-5.
PMID: #29141672# Free -
mutant TP53
20 November 2017See also : TP53
References
More targets, more pathways and more clues for mutant p53.
Garritano S, Inga A, Gemignani F, Landi S.
Oncogenesis. 2013 Jul 1;2:e54. doi:10.1038/oncsis.2013.15.
PMID: #23817466# Free -
bHLH-PAS
20 November 2017bHLH-PAS
See also
ARNT2 -
ARNT2
20 November 2017WKP
Definition: Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors.
The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli.
Under (...)
