WKP
NCOA4 / Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.
It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
Pathology
Molecular profiling of salivary gland intraductal carcinoma revealed a subset of tumors harboring NCOA4-RET and novel TRIM27-RET fusions. (...)
Home > A. Molecular pathology
A. Molecular pathology
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NCOA4
21 August 2018 -
CSTs
24 July 2018cystatins WKP
Definition: The cystatins are a family of cysteine protease inhibitors which share a sequence homology and a common tertiary structure of an alpha helix lying on top of an anti-parallel beta sheet. The family is subdivided as described below.
Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins.
Cystatins mainly inhibit peptidase enzymes (another term for proteases) belonging to peptidase families C1 (papain (...) -
FRS2
13 July 2018WKP
Definition: Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
Pathology
FRS2 is overexpressed and amplified in several cancer types, including prostate cancer.
Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS).
LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon.
The fibroblast growth factor receptor substrate (...) -
KL
14 May 2018Klotho WKP
Definition: Klotho is an enzyme that in humans is encoded by the KL gene.
The KL gene encodes a type-I membrane protein that is related to β-glucuronidases.
Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF.
Also, mutations within the KL protein have been associated with ageing, bone (...) -
MME
8 May 2018CD10 WKP
See also : CD10 -
oncohistones
8 May 2018Definition: Recurrent mutations in histone genes can cause pediatric cancers. These mutations occur at high frequency and lead to the expression of mutant histones that exhibit oncogenic features. Thus, they are termed oncohistones.
Mutations have been found in the genes encoding histone H3 and its variants.
The expression of the oncohistones affects the global chromatin landscape.
Paywall references
Oncohistones: drivers of pediatric cancers. Mohammad F, Helin K. Genes Dev. 2017 Dec (...) -
advanced glycation end-products
7 May 2018AGEs; advanced glycation end-product
Definition: Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars, or glycation.
Pathology
Advanced glycation end products (AGEs) can be a factor in aging and in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic kidney disease, and Alzheimer’s disease.
See also (...) -
ACTA2
19 March 2018WKP
Definition: Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.
Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms (ACTAs ) which have been identified.
Actins (ACTs ) are highly conserved proteins that are involved in cell motility, structure and integrity.
Alpha actins (ACTAs ) are a (...) -
carbon-carbon bond
14 March 2018References
Molecular-decoration technique offers boost to medicinal chemists. 2019 https://www.nature.com/articles/d41586-019-00767-w -
biological organization
24 February 2018biological organisation
|WKP|
Definition : Biological organization is the hierarchy of complex biological structures and biologial systems.
This traditional hierarchy extends from atoms to biospheres. The higher levels of this scheme are often referred to as an ecological organisation concept, or as the field, hierarchical ecology.
Each level in the hierarchy represents an increase in organisational complexity , with each "object" being primarily composed of the previous level’s basic (...)
