Stomach

• familial gastric carcinoma
  20 November 2015

  Hereditary diffuse gastric cancer; familial gastric cancer; hereditary gastric tumors
  Associations
  lobular breast cancer (#18046629#)
  See also
  gastric adenocarcinoma
  gastric tumors
  Open references
  Hereditary diffuse gastric cancer: association with lobular breast cancer. Schrader KA, Masciari S, Boyd N, Wiyrick S, Kaurah P, Senz J, Burke W, Lynch HT, Garber JE, Huntsman DG. Fam Cancer. 2008;7(1):73-82. Review. PMID: #18046629# (...)

• multiple gastric carcinoids
  20 November 2015

  References
  Multiple gastric carcinoids and endocrine cell micronests in type A gastritis: Nuclear morphometric and immunohistochemical analysis. Iwai K, Yao T, Nakamura S, Matsumoto T, Nishiyama K, Iida M, Tsuneyoshi M. Oncol Rep. 2005 Mar;13(3):397-404. PMID: #15706407#

• pediatric auto-immune gastritis
  27 February 2015

  pediatric non-Helicobacter pylori atrophic gastritis
  Although autoimmune atrophic gastritis is classically a disease of elderly adults, recent studies have described the disease in younger adults, particularly in those with other autoimmune diseases and iron-deficiency anemia. Atrophic gastritis in pediatrics is a rare and possibly underdiagnosed entity.
  References
  Pediatric Non-Helicobacter Pylori Atrophic Gastritis: A Case Series. Pogoriler J, Kamin D, Goldsmith JD. Am J Surg Pathol. (...)

• gastric papillary adenocarcinoma
  27 February 2015

  Papillary adenocarcinoma is another common histologic variant often seen in early gastric carcinoma. It tends to affect older people, occur in the proximal stomach, and is frequently associated with liver metastasis and a higher rate of lymph node involvement. Histologically, it is characterized by epithelial projections scaffolded by a central fibrovascular core.

• gastric micropapillary carcinoma
  27 February 2015

  micropapillary carcinoma of stomach
  Micropapillary carcinoma of stomach is a newly recognized histologic variant characterized by small papillary clusters of tumor cells without a distinct fibrovascular core.
  The micropapillary features are often noted in the deep advancing edge of tumor, surrounded by an empty space mimicking retraction artifact.
  Micropapillary carcinoma of stomach, as its counterpart at other organs, tends to form endolymphatic tumor emboli and metastasize to lymph (...)

• gastric endocrine dysplasia
  19 September 2014

  gastric ECL dysplasia
  Synopsis
  defined as large confluent micronodules of ECL cells lying deep in the mucosa, ranging from 150 to 500 microns in size.
  microinfiltration of the lamina propria may be present.
  newly formed stroma is occasionaly noted.
  when the nodules are larger than 0.5 mm and confined to the mucosa, they are classified as microcarcinoids (or intramucosal carcinoid tumors).
  Case reports
  http://www.universitypathologists.com/education/case-of-the-month/may-2010 (...)

• gastrin
  19 September 2014

  Gastrin release from antral G cells is regulated by the following mechanisms:
  luminal regulation: amino acids (particularly phenylalanine and tryptophan) are responsible for food-induced gastrin release. acidity of the gastric content is another major factor (alkaline pH is stimulatory and acidic pH is inhibitory).
  H. pylori: by producing an alkaline pH by acid-neutralizing ammonia catalyzed by the bacterial urease. by production of stimulatory cytokines (interleukin-1 beta and (...)

• antral G cell
  19 September 2014

  Gastrin release from antral G cells is regulated by the following mechanisms:
  luminal regulation: amino acids (particularly phenylalanine and tryptophan) are responsible for food-induced gastrin release. acidity of the gastric content is another major factor (alkaline pH is stimulatory and acidic pH is inhibitory).
  H. pylori: by producing an alkaline pH by acid-neutralizing ammonia catalyzed by the bacterial urease. by production of stimulatory cytokines (interleukin-1 beta and (...)

• gastric neuroendocrine tumor
  19 September 2014

  gastric neuroendocrine tumors
  Gastric neuroendocrine growths (Solcia E, 1988)
  Normal pattern
  Hyperplasia Simple (diffuse) Linear (chain-forming) Micronodular Adenomatoid
  Dysplasia Dysplastic (precarcinoid) lesions Enlarging micronodules Fusing micronodules Microinvasive lesion Nodule with newly formed stroma
  Neoplasia Intramucosal tumor (carcinoid): microcarcinoid, microcarcinoidosis Invasive tumor (carcinoid)
  Open references
  Neuroendocrine pathology of the stomach: the Parma (...)

• neuroendocrine proliferations of the stomach
  19 September 2014

  References
  Neuroendocrine proliferations of the stomach: a pragmatic approach for the perplexed pathologist. Cockburn AN, Morgan CJ, Genta RM. Adv Anat Pathol. 2013 May;20(3):148-57. doi:10.1097/PAP.0b013e31828d185d . PMID: #23574771#

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