Blood

• genetic diseases of fibrinogen
  6 August 2007

  Inherited disorders of fibrinogen

• fibrinogen
  6 August 2007

  Definition: Fibrinogen is an essential protein in coagulation cascade.
  Fibrinogen is produced in the hepatocyte from 3 homologous polypeptide chains, Aα (FGA), Bβ (FGB), and γ (FGG), which assemble to form the hexameric structure (AαBβγ)2.
  The hexamer is characterized by a symmetrical trinodal (D-E-D) structure, with a central E domain connected to 2 peripheral D domains.
  The E domain, which comprises the N-terminal ends of all 6 chains, is prolonged by two three-stranded coiled-coil regions (...)

• hereditary hypofibrinogenemia
  6 August 2007

  Definition: Hypofibrinogenemia is a rare inherited disorder characterized by low levels of circulating fibrinogen, caused by mutations within 1 of the 3 fibrinogen genes.
  Etiology
  As hereditary afibrinogenemia, hereditary hypofibrinogenemia is the result of mutation in one or another of the 3 fibrinogen genes, alpha (FGA) (MIM.134820), beta (FGB) (MIM.134830), or gamma (FGG) (MIM.134850).
  Complete absence of detectable fibrinogen, true congenital afibrinogenemia, was first demonstrated (...)

• quantitative fibrinogen anomalies
  6 August 2007

  quantitative fibrinogen disorders

• pernicious anemia
  12 June 2007

  Biermer’s anemia, Addison’s anemia, or Addison–Biermer anemia WKP eMedicine
  Definition: Pernicious anemia is one of many types of the larger family of megaloblastic anemias. It is caused by loss of gastric parietal cells which are responsible, in part, for the secretion of intrinsic factor, a protein essential for subsequent absorption of vitamin B12 in the ileum.
  Usually seated in an atrophic gastritis, the autoimmune destruction of gastric parietal cells (and autoantibody inactivation (...)

• blood proteome
  25 November 2006

  blood peptidome

• platelet activation
  12 February 2006

  See also
  platelets
  cell activation
  References
  Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007 Dec 13;357(24):2482-94. PMID: #18077812#

• platelets
  12 February 2006

  See also
  platelet activation

• fragmented red cells
  2 February 2006

  Etiology
  thrombotic microangiopathy

• inflammatory anemia
  31 January 2006

  anemia of chronic disease

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