Blood

• Howell-Jolly body-like inclusions
  30 May 2016

  Images
  Howell-Jolly body-like inclusions in neutrophils https://twitter.com/KyleBradleyMD/status/7368931611597250
  Howell-Jolly–like bodies in granulocytes arise secondary to stressed granulopoiesis induced by immunosuppressive drugs, viral infection, or chemotherapy, and must be differentiated from other neutrophil inclusions such as those observed in intracellular bacterial infections, genetic conditions such as Chédiak-Higashi syndrome, or Döhle bodies [Arch Pathol Lab Med. (...)

• Pappenheimer body
  17 May 2016

  Pappenheimer bodies WP
  Pappenheimer bodies are abnormal granules of iron found inside red blood cells on routine blood stain.
  Image
  https://twitter.com/TeamCaptainJohn/status/731162965429395458
  They are a type of inclusion body formed by phagosomes that have engulfed excessive amounts of iron. They appear as dense, blue-purple granules within the red blood cell and there are usually only one or two, located in the cell periphery.
  They are seen in diseases such as sideroblastic (...)

• foamy monocyte in blood
  29 April 2016

  foamy histiocyte in blood; lipid-laden monocyte in blood, spumous monocyte
  Etiology - Examples
  lipidic metabolic diseases GM1 gangliosidosis https://twitter.com/feldstej/status/725869126728716288 http://m.bloodjournal.org/content/127/17/2161/F1.expansion.html
  Images GM1 gangliosidosis https://twitter.com/feldstej/status/725869126728716288 http://m.bloodjournal.org/content/127/17/2161/F1.expansion.html
  See also
  blood (...)

• basophil granulocyte
  7 March 2016

  WP
  Image
  https://twitter.com/guiahistologia/status/687763543475671041

• hereditary spherocytosis
  18 September 2015

  Pathology
  spleen in hereditary spherocytosis
  Associations
  paraspinal extramedullary hematopoiesis and follicular lymphoma (#26369323#)
  Open references
  Paraspinal extramedullary hematopoiesis in hereditary spherocytosis with a concurrent follicular lymphoma: case report and review of the literature. Molina-Urra R, Martinez D, Sagasta A, Carrio A, Setoain X, Nomdedeu B, Campo E. Diagn Pathol. 2015 Sep 15;10(1):158. doi:10.1186/s13000-015-0394-x . PMID: #26369323# (...)

• NPM1-mutated acute myeloid leukemia
  8 July 2015

  NPM1-mutated acute myeloid leukemia encompasses ∼60% of patients with normal karyotype acute myeloid leukemia.
  Minimal residual disease
  Detection of minimal residual disease predicts adverse outcome in patients with acute myeloid leukemia. Currently, minimal residual disease may be detected by RQ-PCR or flow cytometry, both of which have practical and diagnostic limitations.
  Detection of minimal residual disease in NPM1-mutated acute myeloid leukemia can also be made by next-generation (...)

• Trousseau syndrome
  28 August 2013

  Trousseau’s syndrome (TS), named after the French physician Armand Trousseau who first described it in 1865, refers to recurrent or migratory spontaneous venous thrombosis, arterial embolism due to non-bacterial thrombotic endocarditis, or both, in a patient with known or occult malignancy which is usually difficult to diagnose and may even remain elusive until it is disclosed in an autopsy.
  Thrombosis can occur from months to years before cancer is known, and a negative thorough initial (...)

• Persistent polyclonal B-cell lymphocytosis is...
  15 July 2013

  Persistent polyclonal B-cell lymphocytosis is a rare, benign lymphoproliferative disorder characterized by a stable, polyclonal CD19-positive CD5-negative lymphocytosis, the presence of binucleated lymphocytes in peripheral blood, and a polyclonal increase in serum immunoglobulin-M that may occasionally be accompanied by splenomegaly.
  Histopathologic diagnosis of these splenectomy specimens is difficult because of the massive spleen infiltration and the rarity of the descriptions of this (...)

• chronic active EBV disease
  13 January 2012

  A chronic infectious mononucleosis-like illness caused by Epstein–Barr virus (EBV) is called ‘chronic active EBV disease’, which is defined as an EBV-associated lymphoproliferative disease.
  This lymphoproliferative disease is rare and predominantly occurs in Japanese children.
  Pathology
  T/NK cell type chronic active Epstein–Barr virus disease in adults: an underlying condition for Epstein–Barr virus-associated T/NK-cell lymphoma (J Clin Pathol (...)

• T/NK cell type chronic active Epstein–Barr virus disease
  13 January 2012

  T/NK cell type chronic active Epstein–Barr virus disease in adults

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