LOH by regions

• LOH study
  4 October 2004

  Methods
  LOH detection by Southern blot
  LOH detection by microsatellites amplification
  LOH detection by SNPs
  LOH after laser-capture microdissection (LCM)
  LOH from paraffin-embedded and formalin-fixed tissues
  Features
  LOH regions
  allelotype (allelotyping)

• LOH regions
  4 October 2004
• 9p21 LOH
  27 September 2004

  Alteration of the CDKN2A (alias p16) tumor suppressor gene, located on 9p21, occurs frequently in familial and sporadic melanomas.
  Beside CDKN2A, other genes (e.g., CDKN2B, and ARF/p14(ARF), long considered distinct from CDKN2A) on this locus are often deleted or mutated in a large number of tumors including glioma, bladder cancer, and lung cancer.
  Target genes
  CDKN2A (p16 or p16-INK4 and p14-ARF) (MIM.600160)
  CDKN2B (p15 or INK4B) (MIM.600431)
  ARF/p14(ARF)
  Tumors
  melanomas (...)

• 22q LOH
  15 September 2004

  Tumoral types
  liver-cirrhosis nodules (33%) (#15362568#)
  Regions
  22q13 LOH
  Candidate genes
  NF2
  SMARCB1 (INI1/SNF5)
  See also
  Oncobase

• 6q LOH
  15 September 2004

  Tumors or lesions
  liver-cirrhosis nodules (33%) (#15362568#)
  Regions
  6q25 LOH pulmonary carcinomas

• loss of heterozygosity (LOH)
  21 April 2004

  loss of alleles

• tumoral allelotyping
  2 March 2004

  allelotype profiling , allelotyping, cancer allelotyping, genome loss of heterozygosity scan, tumoral allelotype, genome-wide LOH analysis

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