LOH by regions

• 3p21.3 LOH
  3 September 2007

  The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration of this chromosomal region as a lung cancer (LUCA) critical region with tumor suppressor activity.
  Tumors
  pulmonary carcinomas
  neuroblastomas (14%) (#17064406#)
  Target genes
  RASSF1A on 3p21.3 (#17064406#)
  See also
  3p LOH 3p21 LOH
  References
  Elst A, Hiemstra BE, van der Vlies P, Kamminga W, van der Veen AY, Davelaar I, Terpstra P, te Meerman GJ, Gerbens F, Kok K, Buys CH. (...)

• 1p36.2 LOH
  3 September 2007

  The distal part of 1p (1p36.2) is frequently deleted in aggressive neuroblastoma, and the region is believed to harbor one or more tumor suppressor genes relevant to tumor development.
  References
  Fransson S, Martinsson T, Ejeskar K. Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2. Genes Chromosomes Cancer. 2007 Jan;46(1):45-52. PMID: (...)

• 4p LOH
  27 June 2007

  Subregions
  4p16 LOH colorectal adenocarcinoma (40-49%) (#11230704#) cervical squamous cell carcinoma (25%-92%) bladder urothelial carcinoma (22%) (bladder cancer) (4p16.3) (#7970702#) bronchial squamous cell carcinoma 4p16 had been shown to be lost in the transition from carcinoma in situ to invasive tumor.
  References
  Banerjee AK, Read CA, Griffiths MH, George PJ, Rabbitts PH. Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4. Genes (...)

• 1p13 LOH
  22 June 2007

  Tumors
  Wilms tumor
  Candidate genes
  PHTF1
  DCLRE1B
  NRAS
  TRIM33
  References
  Natrajan R, Williams RD, Grigoriadis A, Mackay A, Fenwick K, Ashworth A, Dome JS, Grundy PE, Pritchard-Jones K, Jones C. Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer. 2007 Jun;46(6):607-15. PMID: #17370329#

• 9p23 LOH
  21 June 2007

  Tumors
  cutaneous squamous cell carcinomas (#17420988#)
  lung cancer
  neuroblastoma
  Candidate tumor suppressor genes
  PTPRD
  References
  Purdie KJ, Lambert SR, Teh MT, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM, Young BD. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer. 2007 Jul;46(7):661-9. PMID: (...)

• 1p36.11 LOH
  14 June 2007

  1p36.11 is a region frequently deleted in human cancers.
  Candidate genes
  ARID1A (#17492758#)
  References
  Huang J, Zhao YL, Li Y, Fletcher JA, Xiao S. Genomic and functional evidence for an ARID1A tumor suppressor role. Genes Chromosomes Cancer. 2007 May 10;46(8):745-750 PMID: #17492758#

• 11q21-q24 LOH
  14 June 2007

  Loss of heterozygosity (LOH) at the distal half of chromosome arm 11q is frequent in a variety of human tumors, including breast cancer, and is often associated with poor prognosis.
  Candidate tumor suppressor genes
  MRE11A
  CHEK1
  PPP2R1B
  TSLC1
  ATM
  References
  Allinen M, Peri L, Kujala S, Lahti-Domenici J, Outila K, Karppinen SM, Launonen V, Winqvist R. Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter (...)

• 8p LOH
  6 June 2007

  Tumors
  urothelial carcinomas bladder carcinoma (bladder cancer)

• Chr.20 LOH
  6 June 2007

  Tumors
  colorectal adenocarcinoma (colorectal cancer) 20q LOH: 21.1% 20q LOH: 26.7% Whole Chr.20 LOH: 22.8%
  high LOH frequency: 20p LOH 20q11-q13 LOH
  See also
  sporadic colorectal carcinogenesis

• 11q13 LOH
  7 May 2007

  Tumors
  parathyroid adenoma
  tumors in multiple endocrine neoplasia type 1 (MEN1)

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