Tumoral trisomies

• polysomy 17
  7 December 2011

  Tumors
  mammary carcinomas (breast cancer)
  HER2 gene amplification by fluorescence in situ hybridization and protein expression by immunohistochemistry (IHC) have been used for prognosis and guiding treatment of invasive ductal carcinoma of the breast with trastuzumab.
  Accurate evaluation of HER2 status is important in the management of patients with candidacy for the HER2-targeting therapy.
  Despite previous studies, effects of polysomy of chromosome 17, at which HER2 is located, on (...)

• trisomy 9
  19 January 2011

  AGCOH
  Trisomy 9 occurs in a large spectrum of myeloid and lymphatic malignancies:
  chronic myeloproliferative disorders (CMPD), especially to polycythemia vera (PV)
  acute myeloid leukemias (AML)
  myelodysplastic syndromes (MDS)
  acute lymphoblastic leukemias (ALL) of B-lineage and of T-lineage.
  Strong association to the chronic myeloproliferative disorders (CMPD) and especially to polycythemia vera (PV).
  References
  True malignant histiocytosis with trisomy 9 following primary (...)

• tetrasomy 21
  3 September 2008

  References
  Shin MG, Choi HW, Kim HR, Kim MJ, Baek HJ, Han DK, Kook H, Hwang TJ, Kim HJ, Kim SH, Shin JH, Suh SP, Ryang DW. Tetrasomy 21 as a sole acquired abnormality without GATA1 gene mutation in pediatric acute megakaryoblastic leukemia: a case report and review of the literature. Leuk Res. 2008 Oct;32(10):1615-9. PMID: #18372039#

• trisomy 12p
  29 August 2008

  12p+

• trisomy 19
  1 April 2008

  AGCOH
  Trisomy 19 is frequently encountered in cases of chronic myeloid leukemia (CML) as a secondary abnormality: however, trisomy 19 rarely occurs as a sole chromosomal abnormality.
  Trisomy 19 (+19) as a sole karyotypic aberration is strongly associated with myeloid disorder.
  In a previously published literature review, among 31 patients with isolated +19, 25 were diagnosed with myeloid malignancy, including acute myeloid leukaemia (AML) in 14 cases and myelodysplastic syndrome (MDS) (...)

• tumoral trisomy 18
  21 February 2008

  Diseases
  fibrocystic breast disease (#9614905#)
  References
  Staats B, Bonk U, Gohla G, Bartnitzke S, Bullerdiek J. Two cases of fibrocystic breast disease with polysomy 18 as the sole clonal cytogenetic abnormality. Cancer Genet Cytogenet. 1998 Jun;103(2):91-4. PMID: #9614905#

• trisomy 3
  14 June 2007

  tumoral trisomy 3

• trisomy 16
  29 May 2007

  Isolated
  myelodysplastic syndrome (MDS)
  acute lymphoblastic leukemia (ALL)
  References
  Guillaume B, Ameye G, Dierlamm J, Verhoef G, Duhem C, Ferrant A, Hagemeijer A, Verellen-Dumoulin C, Michaux L. Trisomy 16 as the sole anomaly in hematological malignancies. Three new cases and a short review. Cancer Genet Cytogenet. 2001 Jul 15;128(2):168-71. PMID: #11463459#

• trisomy 15
  29 May 2007

  Trisomy 15 as the sole autosomal anomaly is uncommon in hematological malignancies but could be preferentially associated with myelodysplasia.
  Tumors
  myelodysplasia (myelodysplastic syndromes) (MDS) myeloid related disorders
  References
  Morel F, Le Bris MJ, Herry A, Morice P, De Braekeleer M. Trisomy 15 as the sole abnormality in myelodysplastic syndromes: case report and review of the literature. Leuk Lymphoma. 2003 Mar;44(3):549-51. PMID: (...)

• tumoral trisomy 21
  29 May 2007

  Trisomy 21 as an acquired clonal chromosome change has been described in 642 of the 10,625 human neoplasms with chromosome aberrations known from the cytogenetic literature. A total of 590 of the 642 cases (92%) are hematologic disorders and malignant lymphomas.
  The incidence of trisomy 21 is similar (4.1%-6.7%) in acute myeloid leukemia (AML), chronic myeloid leukemia, myeloproliferative disorders, myelodysplastic syndromes, chronic lymphoproliferative disorders, and malignant lymphomas; (...)

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