Pathogenic agents

• metal fume fever
  7 November 2006

  Metal fume fever (MFF) is a well-known complication of zinc oxide fume inhalation.
  See also
  chemical pneumonitis

• resveratrol
  1 November 2006

  References
  Substance in Red Wine Extends Life of Mice, New York Times, 01/11/2006
  Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006 Jun;5(6):493-506. PMID: #16732220#

• epilepsy drugs
  25 October 2006

  References
  Spurr NK. Pharmacogenetic studies of epilepsy drugs: are we there yet? Trends Genet. 2006 May;22(5):250-2. PMID: #16564110#

• tetrodotoxin
  21 October 2006

  Tetrodotoxin (TTX), first isolated from pufferfish (tetraodontids), is a highly potent neurotoxin that selectively binds to voltage-gated sodium channels (Na(v)) in muscle and nerve tissues causing paralysis and death.
  References
  Soong TW, Venkatesh B. Adaptive evolution of tetrodotoxin resistance in animals. Trends Genet. 2006 Sep 5; PMID: #16959367#

• artemisinins
  31 May 2006

  Combinations of an artemisinin with other antimalarial drugs are now recommended treatments for Plasmodium falciparum malaria in most endemic areas.
  Several individual molecules have been proposed as targets for artemisinins, in addition to the idea that artemisinins might have many targets at the same time.
  Artemisinins could inhibit the parasite-encoded sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) PfATP6. A polymorphism in the gene encoding PfATP6 is associated with in vitro (...)

• topoisomerase inhibitors
  26 March 2006

  topoisomerase poisons, topoisomerase I and II poisons, TOP1 and TOP2 poisons

• duadruplex-interactive drugs
  26 March 2006

  Since 1962, special sequences in DNA that can form secondary DNA structures - such as four-stranded structures in which consecutive runs of guanines are found - have been observed.
  These remained structural curiosities until the late 1980s, when biological roles for these structures were proposed.
  More credence was given to these ideas when proteins were discovered that either bind to the preformed secondary structures or are involved in the formation or resolution of these structures. (...)

• actinomycin D
  26 March 2006

  History
  As early as 1964, Irving Goldberg and co-workers introduced the idea that small molecules, such as actinomycin D, that interact with DNA could have sequence selectivity.
  In 1968, Donald Crothers and co-workers provided biophysical evidence for the intercalation of actinomycin D into DNA.
  X-ray crystallographic studies by Hank Sobell and colleagues at the University of Rochester provided molecular insight into the basis for this sequence selectivity. These studies, although (...)

• code-reading drugs
  26 March 2006

  History
  As early as 1964, Irving Goldberg and co-workers introduced the idea that small molecules, such as actinomycin D, that interact with DNA could have sequence selectivity.
  In 1968, Donald Crothers and co-workers provided biophysical evidence for the intercalation of actinomycin D into DNA.
  X-ray crystallographic studies by Hank Sobell and colleagues at the University of Rochester provided molecular insight into the basis for this sequence selectivity. These studies, although (...)

• antitumor antibiotics
  26 March 2006

  Antibiotics that target cancer cells, such as doxorubicin and bleomycin, have made an important impact on the treatment of cancer patients since the 1960s.
  Knowledge of these and other natural products, such as distamycin, has led to the design of a new generation of DNA-targeted agents, DNA code-reading molecules.
  In contrast to non-specific alkylating agents, anti-tumour antibiotics, such as doxorubicin, seem to have greater selectivity for cancer cells than normal cells, based on their (...)

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