Therapy, Toxics and drugs

• triterpenoid
  5 July 2007

  triterpenoids

• Nexavar
  11 June 2007
• arsenic poisoning
  11 June 2007

  anhydride arsénieux, Trisenox

• aflibercept
  11 June 2007

  VEGF-Trap, Zaltrap Wikipedia
  Definition: Aflibercept is an inhibitor of vascular endothelial growth factor (VEGF). Aflibercept is designed to bind to VEGF-A, VEGF-B, and placental growth factor (PIGF).
  Aflibercept is being co-developed by Sanofi-Aventis and Regeneron Pharmaceuticals.
  Aflibercept is a fusion protein approved in the United States for the treatment of wet macular degeneration. It is under development for the treatment of cancer.
  Clinical trials
  locally advanced or (...)

• gefitinib
  6 June 2007

  Gefitinib is one of EGFR tyrosine kinase inhibitors (TKI / TKIs ).
  See also
  EGFR-associated NSCLC
  Reviews
  Herbst RS, Fukuoka M, Baselga J. Gefitinib—a novel targeted approach to treating cancer. Nat Rev Cancer. 2004 Dec;4(12):956-65. PMID: #15573117#
  References
  Gefitinib Yields Superior Outcomes vs Chemotherapy in EGFR-Mutation-Positive NSCLC, Maurie Markman, MD, Medscape, Posted: (...)

• phytochemicals
  31 May 2007

  Phytochemicals are non-nutrient chemicals derived from plants.
  They have been shown to have anti-inflammatory, anti-oxidative and chemopreventive effects.
  Examples
  resveratrol
  genistein
  epicatechin gallate
  diallyl disulfide
  caffeic acid phenethyl ester
  See also
  chemicals compounds

• COX-2 inhibitors
  31 May 2007

  Specific cyclooxygenase 2 (COX-2) inhibitors may serve for the prevention and treatment of a variety of malignancies.
  See also
  curcumin

• curcumin
  31 May 2007

  Curcumin (U1) has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities.
  Pathology
  Curcumin inhibits COX-2 expression and Erk1/2 activity in NSCLC cells. This inhibition is associated with decreased survival and enhanced induction of apoptosis.
  Curcumin has shown to significantly reduce the growth of orthotopic human non-small cell lung tumors and improve survival of athymic (...)

• Sulindac
  31 May 2007

  Sulindac is a nonsteroidal anti-inflammatory drug.
  It has been reported to be effective in suppressing tumor growth through the induction of p21WAF1/cip1 in human, animal models of colon cancer and colon cancer cells.
  The efficiency of sulindac in the inhibition of cell proliferation (other than the induction of apoptosis) may be through the suppression of beta-catenin pathway in human breast and lung cancer cell (...)

• intoxication with Buckthorn
  26 March 2007

  Karwinskia humboldtiana, coyotillo, tullidora

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