Therapy, Toxics and drugs

• toxic diseases
  23 February 2005

  See List

• bleomycin
  8 February 2005

  Pathology
  bleomycin-induced pneumopathy
  bleomycin-induced scleroderma
  References
  Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer. 2005 Feb;5(2):102-12. PMID: #15685195#

• drug metabolism
  31 January 2005

  References
  Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med. 2005 May 26;352(21):2211-21. PMID: #15917386#

• zidovudine
  27 January 2005

  Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.
  Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.
  See also
  nucleoside analogues
  mitochondrial diseases
  oxydative phosphorylation (OXPHOS (...)

• nucleoside analogues
  27 January 2005

  Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.
  Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.
  See also
  nucleoside analogues
  mitochondrial diseases
  oxydative phosphorylation (OXPHOS (...)

• dioxin
  19 January 2005

  Pathology (Dioxin toxicity)

• NSAIDs
  22 November 2004

  Non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory agents (NSAIAs)

• ACEIs
  22 November 2004

  angiotensin-converting enzyme inhibitors

• ethanol
  22 November 2004

  alcohol
  Pathology
  ethanol toxicity hepatic toxicity : alcohol liver disease steatosis alcoholic hepatitis alcoholic cirrhosis
  See also
  alcoholism
  References
  Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer. 2007 Aug;7(8):599-612. PMID: #17646865#
  Bennett B, Downing C, Parker C, Johnson TE. Mouse genetic models in alcohol research. Trends Genet. 2006 Jul;22(7):367-74. PMID: (...)

• tobacco use
  31 May 2004

  Use of tobacco products, including cigarettes, cigars, pipes, and snuff, is associated with more mortality and morbidity than any other personal, environmental, or occupational exposure.
  Cigarette smoking contributes to 440,000 premature deaths per year in the United States, resulting in an annual economic loss of $157 billion from health-related costs. Lung cancer, cardiovascular disease, and chronic respiratory disease account for most of the deaths related to smoking.
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