G. Tumoral pathology

• Schiller-Duvall body
  14 October 2003

  Schiller-Duvall bodies
  Definition: Schiller-Duvall body is a morphological pattern seen in endodermal sinus tumor (yolk sac tumor). It consists in a central vessel surrounded by tumor cells in a cystic space often lined by flattened tumor cells.
  Schiller-Duvall body is a structure seen in the endodermal sinus pattern of yolk sac tumor. The whole structure being contains in a cystic space often lined by flattened tumor cells.
  Images
  Retroperitoneal mass - AFP, AE1AE3 and glypican (...)

• yolk sac tumor
  14 October 2003

  endodermal sinus tumor, yolk sac tumors

• solitary fibrous tumor
  14 October 2003

  SFTs, SFT
  Definition: Solitary fibrous tumor is a spindle cell tumor first described in the pleura, but also found in multiple extrathoracic sites including the meninges, orbit, nasal and paranasal sinuses. Solitary fibrous tumor represents a spectrum of mesenchymal tumors, encompassing tumors previously termed hemangiopericytoma, which are classified as having intermediate biological potential (rarely metastasizing) in the 2002 World Health Organization classification scheme.
  Images (...)

• pleomorphic fibroma
  14 October 2003

  Pleomorphic fibroma is a benign fibroblastic tumor characterized by pleomorphic, hyperchromatic cells or giant multinucleated cells embedded in a collagenous stroma.
  Images
  https://twitter.com/Valdebran/status/724464458072879105
  Localization
  trunk
  extremities
  subungual (rare) (#14507406#)
  Microscopical synopsis
  paucicellular tumor
  hyperchromatic spindled, pleomorphic, floret-like giant cells embedded in haphazardly arranged collagen bundles in the dermis
  no mitotic (...)

• aneurysmal fibrous histiocytoma
  14 October 2003

  Microscopical synopsis
  blood-filled spaces: artefact-like clefts to cystic areas mimicking cavernous vascular channels but devoid of an endothelial lining
  prominent haemosiderin deposition with numerous siderophages
  giant cells
  storiform proliferation of histiocyte-like and fibroblast-like cells in a capillary-rich stroma
  cellular polymorphism
  hyalinized collagen bundles surrounded by tumour cells in the periphery of the lesion
  epidermal hyperplasia (88%) (#7607620#) (...)

• angiomatoid fibrous histiocytoma
  14 October 2003

  Definition: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation.
  Images
  https://twitter.com/JMGardnerMD/status/735824693718974464
  Angiomatoid "malignant" fibrous histiocytoma is considered to be a low-grade sarcoma of childhood, and, with its fibrous pseudocapsule, angiomatoid change, dense lymphoplasmacytic response, and proliferation of spindled or round cells, has been classified as a fibrohistiocytic neoplasm. (...)

• mantle cell lymphoma
  30 September 2003

  small cell mantle lymphoma
  Definition: Mantle cell lymphoma (MCL) is characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in overexpression of cyclin-D1 (CCND1) in the vast majority of cases.
  Images
  Mantle cell lymphoma with prominent nodular pattern
  https://twitter.com/DanBabuMD/status/759573102007234560
  https://twitter.com/KyleBradleyMD/status/855422646305124352
  Digital cases
  HPC:286 : Nodal mantle cell lymphoma
  HPC:301 : Mantle cell lymphoma of the (...)

• diffuse large B-cell lymphoma
  23 September 2003

  DLBCL
  Definition: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin.
  2 main types :
  Germinal Center B-Cell like DLBCL / GCB-DLBCL
  Activated B-cell like DLBCL / ABC-DLBCL
  The greatest difference resided between distinct populations of germinal centre (GC) cell tumours; the first being CD10-, Bcl-6+, MUM-1- and the second CD10+ Bcl-6+ MUM-1+. The former group displayed median (...)

• neuroblastoma
  19 July 2003

  neuroblastomas

• tumorigenesis
  13 July 2003

  carcinogenesis, oncogenesis, tumoral transformation
  Definition: Tumorigenesis is a collection of complex genetic diseases characterized by multiple defects in the homeostatic mechanisms that regulate cell growth, proliferation and differentiation.
  Cancer is caused by uncontrolled proliferation and the inappropriate survival of damaged cells, which results in tumour formation. Cells have developed several safeguards to ensure that cell division, differentiation and death occur correctly (...)

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