G. Tumoral pathology

• angiofibromas
  15 June

  Types
  cellular angiofibroma
  juvenile angiofibroma
  Examples
  https://twitter.com/VKazlouskaya/status/927551847723913216

• tuberous anomalies
  15 June

  Examples
  Koenen tumors in this patient with tuberous sclerosis - tuber https://twitter.com/Valdebran/status/696873001271230464
  tuberous tumors tuberous dermal melanocytic naevus

• GLI1-rearranged malignant epithelioid tumor
  15 June

  Open references
  A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions. Antonescu CR, Agaram NP, Sung YS, Zhang L, Swanson D, Dickson BC. Am J Surg Pathol. 2018 Apr;42(4):553-560. doi:10.1097/PAS.0000000000001010. PMID: #29309307# (...)

• plexiform fibromyxoma
  15 June

  Molecular pathology
  GLI1-MALAT1 fusion gene
  Open references
  Pediatric plexiform fibromyxoma: A PRISMA-compliant systematic literature review. Fukazawa M, Koga H, Hiroshige S, Matsumoto T, Nakazono Y, Yoshikawa Y. Medicine (Baltimore). 2019 Jan;98(3):e14186. doi:10.1097/MD.0000000000014186. PMID: #30653169# Free
  Plexiform Fibromyxoma: A Rare Gastric Tumor. Wambura C, Surani S. Case Rep Gastrointest Med. 2017;2017:4014565. doi:10.1155/2017/4014565. PMID: #29318062# Free
  A (...)

• cherry hemangioma
  13 June

  Molecular pathology
  High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms. 2019.
  https://www.nature.com/articles/s41379-019-0284-y

• benign fusiform cell tumors
  30 April

  Benign Spindle Cell Lesions
  Spindle cell lesions cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors.
  The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflammatory myofibroblastic tumor; fascicular variant of pseudoangiomatous stromal hyperplasia) and tumors (myofibroblastoma, benign fibroblastic spindle cell tumor, leiomyoma, (...)

• PIK3CA-related overgrowth spectrum disorder
  16 March

  Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
  See also : PIK3CA
  Definition : PIK3CA is one of the most commonly mutated genes in solid cancers. PIK3CA mutations are also found in benign overgrowth syndromes, collectively known as PIK3CA-related overgrowth spectrum (PROS).
  As in cancer, PIK3CA mutations in PROS arise postzygotically, but unlike in cancer, these mutations arise during embryonic development, with their timing and location critically influencing the resulting (...)

• RET-rearranged tumors
  16 March

  RET-driven cancers
  Types (Examples)
  RET-rearranged carcinomas RET-rearranged thyroid carcinomas RET-rearranged pulmonary adenocarcinoma RET-rearranged colorectal adenocarcinoma
  RET-rearranged fusiform cell tumors

• plasmacytoid tumors
  13 March

  Examples
  plasmacytic tumors
  plasmacytoid melanoma
  plasmacytoid urothelial carcinoma https://twitter.com/Rus13Co/status/1105737198928826368
  See also
  plasmacytoid appearance

• inflammatory background
  12 March

  Examples
  inflammatory myofibroblastic tumor Examples : https://twitter.com/daniel_berney/status/1095299013002301444
  myxoinflammatory fibroblastic sarcoma https://twitter.com/mufster82/status/1105207586511638529
  inflammatory stroma in carcinomas
  See also
  architectural patterns

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