G. Tumoral pathology

• gangliocytic paraganglioma
  16 November

  Images
  https://twitter.com/jake_bledsoe/status/1195476228830060544
  See also
  gangliocytic anomalies
  paraganglioma

• palisaded architecture
  12 November

  Images
  palisaded myofibroblastoma https://twitter.com/kriyer68/status/1129242436310425600
  See also
  myofibroblastoma

• palisaded myofibroblastoma
  12 November

  Images
  Palisaded Myofibroblastoma https://twitter.com/kriyer68/status/1129242436310425600
  See also
  palisaded architecture / palisaded myofibroblastoma
  myofibroblastoma

• ALK-rearranged histiocytosis
  11 November

  ALK-positive histiocytosis
  ALK-positive histiocytosis is a systemic histiocytic proliferation of early infancy with hepatosplenomegaly and dramatic hematological disturbances.
  The clinicopathological spectrum of ALK-positive histiocytosis is broader than originally described, and this entity is characterized by frequent presence of KIF5B-ALK gene fusion.
  It has been recommended that every unusual histiocytic proliferative disorder, especially disseminated lesions, be tested for ALK (...)

• STK11-mutated tumors
  10 November

  Pathology
  STK11 somatic mutations in STK11-mutated tumors (#10079245#): STK11-mutated pulmonary adenocarcinoma (#25695224#, #23995788#, #22460425#, #21191700#, #12097271#, #10079245#) STK11-mutated cervical adenocarcinoma (#10079245#)
  See also
  STKs / STK11
  tumors mutated genes in tumors gene-mutated tumors

• dMMR tumors
  10 November

  DNA mismatch repair deficient tumors ; MSI-H
  See also
  DNA mismatch repair
  microsatellite instability

• NTRK3-rearranged fibrosarcoma
  9 November

  NTRK3-rearranged fibrosarcomas
  NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy.
  CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing.
  Paywall references
  Novel NTRK3 Fusions in Fibrosarcomas of Adults. Yamazaki (...)

• NTRK3-rearranged fusiform cell tumors
  8 November

  soft tissue spindle cell tumors with NTRK3 gene rearrangements
  NTRK3-rearranged tumors other than infantile fibrosarcomas (IFSs) harboring the canonical ETV6-NTRK3 fusions are uncommon, and include mainly inflammatory myofibroblastic tumors and gastrointestinal stromal tumors.
  Examples
  NTRK3-rearranged fibrosarcoma
  References
  The histologic spectrum of soft tissue spindle cell tumors with NTRK3 gene rearrangements. Suurmeijer AJ, Dickson BC, Swanson D, Zhang L, Sung YS, Huang HY, (...)

• NTRK-rearranged tumors
  8 November

  TRK-rearranged tumor ; NTRKs fusion tumor
  Examples
  NTRK-rearranged mesenchymal tumors
  Soft Tissue Sarcoma with LMNA-NTRK1 Gene Fusion
  NTRK-rearranged inflammatory myofibroblastic tumor
  -* NTRK-rearranged adenocarcinomas NTRK-rearranged esophageal adenocarcinoma NTRK-rearranged gastric adenocarcinoma NTRK-rearranged colorectal adenocarcinoma NTRK-rearranged salivary adenocarcinoma secretory carcinoma of salivary gland with ETV6-NTRK3 fusion
  NTRKs in hematological malignancies. (...)

• proliferative palmar fibromatosis
  30 October

  proliferative Dupuytren disease
  Other subtypes :
  fibrocellular palmar fibromatosis : a fibrocellular type characterized by the presence of a reticulin network, Manual word wrap
  fibrous palmar fibromatosis : a fibrous type with few cells.
  This histologic classification seems to have a prognostic value because the recurrence rate is higher in type I (70%) and lower in type III (18%). The risk of extension did not correlate with the histologic type.
  Paywall references
  Prediction of (...)

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