Tumoral translocations

• t(4;6)(q22;q15)
  12 April 2012

  The t(4;6)(q22;q15) occurs in 11.7% of patients.
  The t(4;6)(q22;q15) is not independently associated with patient outcome. However, it occurs more frequently in high clinical T stage, high tumor volume specimens and in those with high baseline PSA (P=0.001, 0.001 and 0.01, respectively).
  The t(4;6)(q22;q15) occurs more frequently in samples with two or more TMPRSS2:ERG fusion genes caused by internal deletion than in samples without these genomic alterations, but this correlation is not (...)

• t(6;9)(p23;q34)
  2 January 2012

  Pathology
  DEK-NUP214 (CAN-DEK) fusion gene
  The t(6;9)(p23;q34) associated DEK/CAN (CAN-DEK) fusion protein targets a population of long-term repopulating hematopoietic stem cells for leukemogenic transformation. (#20827285#)
  Acute myelogenous leukemia (AML) with chromosomal translocation t(6;9)(p23;q34) is a rare disease with poor prognosis and distinct clinical and morphologic features.
  t(6;9) results in a chimeric fusion gene between DEK (6p23) and CAN/NUP214 (9q34).
  t(6;9) is (...)

• t(3;20)(q27;q13.3)
  11 October 2011

  Tumors
  t(3;20)(q27;q13.3) in a childhood ovary teratoma with associated malignant germ cell component. Brassesco MS, Castro-Gamero AM, Valera ET, Neder L, Elias J Jr, Tone LG. Pediatr Blood Cancer. 2009 Mar;52(3):398-401. PMID: #19023889#
  See also
  3q27
  References
  3q27 aberrations in a childhood ovary teratoma with associated malignant germ cell component. Brassesco MS, Castro-Gamero AM, Valera ET, Neder L, Elias J Jr, Tone LG. Pediatr Blood Cancer. 2009 Mar;52(3):398-401. PMID: (...)

• t(5;12)(q33;p13)
  14 June 2011

  t(5;12)(q33;p13.1)

• t(1;5)(p32;q31)
  14 June 2011

  References
  Deregulated expression of the TAL1 gene by t(1;5)(p32;q31) in patient with T-cell acute lymphoblastic leukemia. François S, Delabesse E, Baranger L, Dautel M, Foussard C, Boasson M, Blanchet O, Bernard O, Macintyre EA, Ifrah N. Genes Chromosomes Cancer. 1998 Sep;23(1):36-43. PMID: #9713995#

• t(1;1)(p36;q21)
  3 May 2011
• t(12;15)(p13;q25)
  3 May 2011

  AGCOH Mitelman database (CGAP - NCBI) CancerChromosomes (NCBI)
  The t(12;15)(p13;q25) forms the ETV6-NTRK3 fusion gene.
  References
  A unique translocation of the TEL gene in a case of acute myelogenous leukemia with inv(12)(p13q15). Setoyama M, Tojo A, Nagamura F, Asano S, Ishimae M, Eguchi M, Kamada N. Blood. 1998 ; 92 (4) : 1454-1455. PMID #9694736#
  Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Eguchi M, Eguchi-Ishimae M, Tojo A, (...)

• t(4;22)(q31;q12)
  17 March 2011

  The t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion (#21113140#).
  Tumors
  extraskeletal Ewing sarcoma/primitive neuroectodermal tumor (#21113140#)
  References
  A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. Sumegi J, Nishio J, Nelson M, Frayer RW, Perry D, Bridge JA. Mod Pathol. 2011 Mar;24(3):333-42. PMID: #21113140# (...)

• t(X;9)(q26;q32)
  14 December 2010

  Tumors
  aneurysmal bone cyst (ABC) solid variant of aneurysmal bone cyst Aneurysmal bone cysts (ABC) are locally destructive bone lesions occurring predominantly in young adults.
  See also
  t(16;17)(q22;p13)
  References
  Solid variant of aneurysmal bone cyst with a novel (X;9) translocation. Kenney B, Richkind KE, Zambrano E. Cancer Genet Cytogenet. 2007 Oct 15;178(2):155-9. PMID: (...)

• t(X;4)(q22;q31)
  14 December 2010

  t(X;4)(q22;q31.3)

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