Pancreas

• pancreatic poorly differentiated neuroendocrine carcinoma
  19 October 2016

  Poorly differentiated neuroendocrine carcinomas of the pancreas
  Open references
  Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases.
  Basturk O, Tang L, Hruban RH, Adsay V, Yang Z, Krasinskas AM, Vakiani E, La Rosa S, Jang KT, Frankel WL, Liu X, Zhang L, Giordano TJ, Bellizzi AM, Chen JH, Shi C, Allen P, Reidy DL, Wolfgang CL, Saka B, Rezaee N, Deshpande V, Klimstra DS.
  Am J Surg Pathol. 2014 Apr;38(4):437-47. (...)

• hyaline globules in pancreatic tumors
  19 October 2016

  Open references
  Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH. Am J Surg Pathol. 2011 Jul;35(7):981-8.
  doi:10.1097/PAS.0b013e31821a9a14.
  PMID: #21677537# Free

• GNAS-associated pnacreatic neoplasms
  19 October 2016

  Open references
  GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".
  Matthaei H, Wu J, Dal Molin M, Shi C, Perner S, Kristiansen G, Lingohr P, Kalff JC, Wolfgang CL, Kinzler KW, Vogelstein B, Maitra A, Hruban RH.
  Am J Surg Pathol. 2014 Mar;38(3):360-3. doi: 10.1097/PAS.0000000000000117.
  PMID: 24525507 (...)

• incipient IPMN
  19 October 2016

  incipient IPMNs
  Incipient intraductal papillary mucinous neoplasms (IPMNs) are poorly described subcentimeter pancreatic cysts with papillae and mucin similar to IPMNs.
  They are larger than pancreatic intraepithelial neoplasia but do not meet the cutoff size for IPMNs (≥ 1 cm).
  See also : intraductal papillary mucinous neoplasm ( IPMN )
  Molecular biology
  GNAS codon 201 mutations are hallmark genetic alterations of IPMNs.
  See also
  incipient intraductal papillary mucinous neoplasms (...)

• pancreatic mucinous non-neoplastic cyst
  16 October 2016

  mucinous non-neoplastic cyst of the pancreas; MNNC
  Although a mucinous nonneoplastic cyst (MNNC) of the pancreas is defined as a benign nonneoplastic lesion with no malignant potential, its histogenesis and etiology are still uncertain.
  Although the genomic mutation rate detected in MNNC is relatively low, some results indicate that MNNCs may acquire genetic alteration similar to low-grade pancreatic intraepithelial neoplasia, furthering debate of the true nature of these lesions.
  In one (...)

• molecular pathology of pancreatic FNA
  15 October 2016

  EUS FNA of the pancreas; molecular pathology of FNA of the pancreas
  mutational profiling
  next-generation sequencing (NGS)
  mutational profiling of the cytocentrifugation supernatant fluid
  In a study, 5/23 samples cytologically confirmed as adenocarcinoma showed detectable mutations both in the microdissected slide-based cytology cells and in the cytocentrifugation supernatant. (#24051700#)
  While most mutations detected were present in both microdissected slides and supernatant (...)

• pancreatectomy
  5 October 2016

  Types
  duodenopancreatectomy / cephalic duodenopancreatectomy Whipple procedure, or Kausch-Whipple procedure
  caudal pancreatectomy
  Images
  Whipple gross specimen common biliary duct adenocarcinoma https://twitter.com/marcoslepe/status/746759520764960768
  See also
  surgical procedures

• pancreatic specimens
  5 October 2016

  Types
  cytology
  biopsy
  pancreatectomy pancreaticoduodenectomy / cephalic pancreatectomy / Whipple procedure
  See also
  specimens

• pancreatic ductal anomalies
  30 September 2016

  Duct Lesions of the Pancreas
  Normal ductal and ductular epithelium
  The normal ductal and ductular epithelium is a cuboidal to low-columnar epithelium with amphophilic cytoplasm. Mucinous cytoplasm, nuclear crowding and atypia are not seen.
  Types
  squamous metaplasia (transitional metaplasia)
  a process in which the normal cuboidal ductal epithelium is replaced by mature squamous or transitional epithelium without atypia.
  PanIN-1A: (Pancreatic Intraepithelial Neoplasia 1-A)
  These (...)

• pancreatic atypical ductal hyperplasia
  30 September 2016

  Atypical ductal hyperplasia of the pancreas
  Atypical ductal hyperplasia of the pancreas is thought to be a precancerous lesion.
  Synopsis
  hyperplastic epithelium without atypia
  References
  Atypical ductal hyperplasia of the pancreas associated with a stricture of the main pancreatic duct. Kogire M, Tokuhara K, Itoh D, Koshiba T, Sato M, Yamanaka H, Mohri Y, Kadota E. J Gastroenterol. 2003;38(3):295-7. PMID: (...)

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