Pancreas

• beta-cells
  20 April 2004

  pancreatic beta-cells

• pancreatic acinar cell carcinoma
  9 March 2004

  Acinar cell carcinoma of pancreas PO
  Images
  pancreatic acinar cell carcinoma https://twitter.com/KUSAURAP/status/578069039697633280 https://twitter.com/RMeunierMD/status/584066836867735553 https://twitter.com/KUSAURAP/status/738741327391653888 https://twitter.com/mreyesm/status/713393408094683136 https://twitter.com/KUSAURAP/status/681722974743834624 https://twitter.com/CaDxPath/status/847705934612672516
  Synopsis
  monotounous acini with mild atypia.
  Differential diagnosis (...)

• fibrocalculous pancreatic diabetes
  14 November 2003

  Susceptibility gene
  SPINK1 variants (12187509)

• chronic pancreatitis
  14 November 2003

  Etiology
  hereditary chronic pancreatitis (HCP)
  alcoholic chronic pancreatitis
  cystic fibrosis-associated chronic pancreatitis
  fibrocalculous pancreatic diabetes (FCPD)
  Susceptibility
  SPINK1 variants
  KRT8 mutations (KRT8-associated chronic pancreatitis)
  References
  Bhanot UK, Moller P, Hasel C. Dichotomy of fates of pancreatic epithelia in chronic pancreatitis: apoptosis versus survival. Trends Mol Med. 2006 Aug;12(8):351-7. PMID: #16828345#
  Cavestro GM, Frulloni L, Nouvenne (...)

• pancreatitis
  14 November 2003

  Classification
  acute pancreatitis
  chronic pancreatitis

• pancreatic solid pseudopapillary tumor
  12 November 2003

  PSPPT; solid-pseudopapillary tumor of the pancreas, Frantz tumor, Frantz’s tumor; solid pseudopapillary tumor of the pancreas; ICD-O codes Solid pseudopapillary neoplasm 8452/1, Solid pseudopapillary carcinoma 8452/3; pancreatic solid pseudopapillary tumor; pancreatic solid and pseudopapillary tumor; Solid-pseudopapillary neoplasm of the pancreas PathConsult
  Definition: Solid pseudopapillary neoplasms of the pancreas are rare pancreatic tumors with mostly benign behavior, affecting (...)

• pancreatic ductal adenocarcinoma
  29 October 2003

  exocrine pancreatic cancer, pancreatic adenocarcinomas, pancreatic cancer; pancreas cancer
  Digital case
  JRC:10443 : cutaneous metastasis of a pancreatic adenocarcinoma.
  Definition: Pancreatic adenocarcinoma is the fifth leading cause of cancer death with a 5-year survival rate of less than 5%.
  Molecular biology The most prevalent genetic alterations were in KRAS (78% of patients), TP53 (tumor protein p53) (25%), and SMAD4 (SMAD family member 4) (8%). (#26378065#)
  genic (...)

• pancreatic development
  29 October 2003

  Molecular signaling pathways FOXA2 IPF1
  Differentiation of early foregut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation events controlled by various transcription factors.
  The forkhead/winged helix transcription factor FOXA2 (formerly HNF-3beta) is a major upstream regulator of IPF1 (human homolog of murine Pdx1), a homeobox gene essential for pancreatic development.
  IPF1 is also essential for the maintenance of glucose homeostasis. (...)

• lymphoplasmacytic sclerosing pancreatitis
  3 October 2003

  Lymphoplasmacytic sclerosing pancreatitis with cholangitis is a variant of primary sclerosing cholangitis extensively involving pancreas.

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