Types

 cANCA: diffuse cytoplasmic staining by immunofluorescence

• serine proteinase-3 (PR3) is the predominant antigen for C-ANCA
• Wegener granulomatosis (80-95%)

 pANCA: perinuclear staining

• P-ANCAs are usually directed against myeloperoxidase (MPO)
• Wegener granulomatosis (5-20%)
• microscopic polyangiitis ++

 atypical pattern

• inflammatory bowel disease
• systemic immune-mediated diseases
• infections

See also

 ANCA-associated vasculitis