Isochromosome 17q, or i(17q), is one of the most common structural abnormalities observed in human neoplasms.
hematologic malignancies
- testicular granulocytic sarcoma (18262059)
medulloblastoma (most frequent chromosomal rearrangement) (16419060)
References
Bettio D, Venci A, Sarina B. Near-tetraploid karyotype with an isochromosome 17q as the sole structural chromosomal rearrangement in a case of testicular granulocytic sarcoma. Cancer Genet Cytogenet. 2008 Feb;181(1):69-71. PMID: 18262059
Mendrzyk F, Korshunov A, Toedt G, Schwarz F, Korn B, Joos S, Hochhaus A, Schoch C, Lichter P, Radlwimmer B. Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats. Genes Chromosomes Cancer. 2006 Apr;45(4):401-10. PMID: 16419060