alveolar soft part sarcoma

Alveolar soft-part sarcoma is a rare soft tissue malignant tumor that commonly arises in skeletal muscles or musculofascial planes in children and young adults.

Cytogenetics

- t(X;17)(p11;q25) (12769020, 12045953, 11244503)(TFE3/ASPL gene fusion)

Molecular biology

- TFE3/ASPL gene fusion

Prognosis

- frequent metastases to lung, brain, and bone

References

- Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R. Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology. 2007 Jun;50(7):881-6. PMID: 17543078

[ Return to site page ]