Fusion proteins

Articles

• EWSR1/WT1
  18 June 2007

  EWS/WT1

• MLL-MAML2
  14 June 2007

  MLL/MAML2 gene fusion

• CREB1-EWSR1
  29 August 2007

  EWSR1/CREB1; EWSR1-CREB1
  Fusion gene fornation by translocation
  CREB1 at 2q32-q34 and EWSR1 at 22q12
  Tumors
  clear cell sarcoma ( soft parts melanoma ) (#17000668#)
  angiomatoid fibrous histiocytoma (AFH) (#17724745#)
  Ewing sarcoma / small blue round cell tumor (#20598147#)
  See also
  CREBSs
  ATF1-FUS
  ATF1-EWSR1
  Open references
  Small blue round cell tumor of the interosseous membrane bearing a t(2;22)(q34;q12)/EWS-CREB1 translocation: a case report. Pacheco M, Horsman DE, (...)

• NPM1-ALK
  23 July 2007

  NPM/ALK, NPM1/ALK

• FIP1L1-PDGFRA
  23 July 2007

  PDGFRA/FIP1L1

• EML4-ALK
  23 July 2007

  EML4/ALK
  The fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target.
  In non-small cell lung cancer, epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase (ALK) gene rearrangements have a major impact upon the level of response to treatment with specific tyrosine kinase inhibitors.
  Pathology
  ALK-EML4 fusion gene in :
  non-small-cell lung cancer (6.7% of NSCLC) (#17625570#)
  ALK-associated (...)

• EWSR1/ETSs
  8 July 2007

  EWS-ETS oncoproteins

• fusion gene
  21 June 2007

  fusion proteins

• ERG-TMPRSS2
  27 June 2007

  TMPRSS2/ERG gene fusion; TMPRSS2:ERG
  Definition: TMPRSS2/ERG gene fusion of the 5’-untranslated region of TMPRSS2 (21q22.3) with ERG at 21q22.2 from the ETS transcription factor family members is observed in 50% prostate cancer (prostatic adenocarcinoma) (#17584912#)
  The fusion of TMPRSS2 with ETS genes was reported by Tomlins et al in 2005 as the first recurrent genomic alteration in prostate cancer and has been now confirmed by multiple independent groups.
  The ETS-related gene (ERG) is (...)

• LPP-HMGA2
  9 October 2008

  Pathology
  LPP-HMGA2 gene fusion by t(3;12)(q27;q14-15)
  lipomas (#3349440#, #8812423#, #7670494#)
  pulmonary chondroid hamartoma (HPC)
  References
  Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG, Oliveira AM. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008 Jun;32(6):951-4. PMID: #18551755#
  Lemke I, Rogalla P, Grundmann F, Kunze WP, (...)

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