Fusion proteins

Articles

• EWS/FEV
  26 October 2004

  Fusion protein created by t(2;22) in Ewing sarcoma.
  EWS/FEV joins EWS on Chr.22 and FEV on Chr.2

• TCF3/PBX1
  8 June 2004

  TCF3-PBX1

• PLAG1-TCEA1
  11 September 2007

  TCEA1-PLAG1
  Pathology
  TCEA1-PLAG1 fusion gene formation by cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas (#16736500#)
  See also
  TCEA1
  PLAG1
  References
  Asp J, Persson F, Kost-Alimova M, Stenman G. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer. 2006 Sep;45(9):820-8. PMID: (...)

• BCOR-CCNB3
  15 April 2009

  BCOR/CCNB3; CCNB3-BCOR; CCNB3/BCOR
  Pathology
  A new subtype of bone sarcoma is defined by BCOR-CCNB3 gene fusion. (#22387997#) CCNB3 immunohistochemistry is a powerful diagnostic marker for this subgroup of sarcoma and that overexpression of BCOR-CCNB3 or of truncated CCNB3 activates S phase in NIH3T3 cells. The intrachromosomal X-chromosome fusion represents a new subtype of bone sarcoma caused by a newly identified gene fusion mechanism.
  Open references BCOR-CCNB3 fusions are (...)

• TRC8/FHIT
  21 April 2004

  Pathology
  TRC8 gene was interrupted by a t(3;8)(p14.2;q24.1) translocation in a family with hereditary renal and non-medullary thyroid cancer (#470981#, #12522559#).
  This translocation fuses FHIT with the patched-related gene TRC8 (#9689122#) with formation of the TRC8/FHIT fusion gene.
  TRC8/FHIT fusion gene in familial renal cell carcinoma (#470981#, #9689122#)
  TRC8/FHIT fusion gene in sporadic renal cell carcinoma (...)

• ATF1-FUS
  15 November 2003

  FUS-ATF1
  Pathology
  FUS-ATF1 fusion gene in angiomatoid fibrous histiocytoma (#11063792#)
  See also
  FUS
  ATF1

• FGFR3-TACC3
  17 May 2016

  Open References
  The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. Parker BC, Annala MJ, Cogdell DE, Granberg KJ, Sun Y, Ji P, Li X, Gumin J, Zheng H, Hu L, Yli-Harja O, Haapasalo H, Visakorpi T, Liu X, Liu CG, Sawaya R, Fuller GN, Chen K, Lang FF, Nykter M, Zhang W. J Clin Invest. 2013 Feb;123(2):855-65. doi:10.1172/JCI67144 . PMID: #23298836# (Free)
  Transforming fusions of FGFR and TACC genes in human glioblastoma. Singh D, Chan JM, Zoppoli P, Niola (...)

• TLS/CHOP
  3 June 2004

  TLS-CHOP

• FUS/BBF2H7
  3 June 2004

  Pathology
  FUS/BBF2H7 fusion gene by t(7;16)(q33;p11) in fibromyxoid sarcoma (#12915480#)

• PML/RARA
  2 June 2004

  PML-RARA fusion protein or fusion gene

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