Fusion proteins

Articles

• EWSR1-PBX1
  3 September 2008

  EWSR1/BX1
  Tumors
  EWSR1-PBX1 gen fusion in : myoepitheliomas and myoepithelial tumors
  Paywall References
  Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature. Leduc C, Zhang L, Öz B, Luo J, Fukuoka J, Antonescu CR, Travis WD. Am J Surg Pathol. 2016 Feb;40(2):212-23. doi:10.1097/PAS.0000000000000560. PMID: #26645726#
  Brandal P, Panagopoulos I, Bjerkehagen B, Gorunova L, Skjeldal S, Micci F, Heim S. Detection of a t(1;22)(q23;q12) (...)

• tyrosine kinase fusion proteins
  27 August 2008

  fusion genes involving tyrosine kinases; kinase fusions; kinase gene fusion
  The Philadelphia chromosome and the reciprocal translocation t(9;22)(q34.1;q11.23)
  The classic example of a cytogenetic abnormality leading to the formation of a chimeric fusion gene is the Philadelphia chromosome, a truncated chromosome 22 that is present in virtually all patients with chronic myeloid leukemia, in approximately 20% of patients with acute lymphoblastic leukemia, and in rare cases of acute myeloid (...)

• LPP-HMGA2
  9 October 2008

  Pathology
  LPP-HMGA2 gene fusion by t(3;12)(q27;q14-15)
  lipomas (#3349440#, #8812423#, #7670494#)
  pulmonary chondroid hamartoma (HPC)
  References
  Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG, Oliveira AM. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008 Jun;32(6):951-4. PMID: #18551755#
  Lemke I, Rogalla P, Grundmann F, Kunze WP, (...)

• MLL-SEPT9
  26 October 2010

  MLL/SEPT9

• FUS-DDIT3
  17 March 2011

  References
  Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay. Powers MP, Wang WL, Hernandez VS, Patel KS, Lev DC, Lazar AJ, López-Terrada DH. Mod Pathol. 2010 Oct;23(10):1307-15. PMID: #20581806# [Free]

• BRD4-NUT
  4 December 2009

  BRD4/NUT
  Definition: The protein encoded by BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Two alternatively spliced transcript variants have been described.
  Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting.
  Pathology
  BRD4-NUT poorly differentiated carcinomas ( BRD4-NUT midline carcinoma )
  BRD4 has been (...)

• PAX7-FOXO1
  25 November 2003

  PAX7-FKHR, PAX7/FOXO1A
  Pathology
  alveolar rhabdomyosarcoma
  References
  Collins MH, Zhao H, Womer RB, Barr FG. Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR or PAX7-FKHR gene fusions. Med Pediatr Oncol. 2001 Aug;37(2):83-9. PMID: #11496344#
  Barr FG. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene. 2001 Sep 10;20(40):5736-46. PMID: (...)

• NUP98/HOXA9
  25 November 2003

  Pathology
  acute myeloid leukemia (AML) with t(7;11)(p15;p15)
  chronic myelogenous leukemia with t(7;11)(p15;p15)

• CHCHD7/PLAG1
  11 September 2007

  Pathology
  CHCHD7/PLAG1 fusion gene formation by cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas (#16736500#)
  References
  Asp J, Persson F, Kost-Alimova M, Stenman G. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer. 2006 Sep;45(9):820-8. PMID: (...)

• PLAG1-TCEA1
  11 September 2007

  TCEA1-PLAG1
  Pathology
  TCEA1-PLAG1 fusion gene formation by cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas (#16736500#)
  See also
  TCEA1
  PLAG1
  References
  Asp J, Persson F, Kost-Alimova M, Stenman G. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer. 2006 Sep;45(9):820-8. PMID: (...)

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