Fusion proteins

Articles

• FUS-FEV
  22 May 2008

  FUS/FEV; FEV-FUS
  Pathology
  FUS/FEV fusion gene in Ewing sarcoma by t(2;16)(q35;p11) (#17620387#)
  References
  Ng TL, O’Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE. Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.J Mol Diagn. 2007 Sep;9(4):459-63. PMID: #17620387#

• CRTC1-MAML2
  8 March 2004

  WAMTP1/MAML2, TORC1/MAML2, MECT1/MAML2, CRTC1/MAML2, MECT1/MAML2; MAML2-MECT1
  Definition: Fusion of the CREB regulated transcription coactivator MECT1 (a.k.a. CRTC1, TORC1, or WAMTP1) to the Notch coactivator MAML2 is a characteristic feature of low-grade mucoepidermoid carcinomas of salivary and bronchial glands.
  The MECT1-MAML2 fusion protein acts by inducing transcription of cAMP/CREB target genes, and this activity is crucial for the transforming properties of the protein.
  Pathology (...)

• CXCR7-HMGA2
  27 October 2004

  HMGA2-RDC1
  Pathology
  HMGA2-CXCR7 fusion gen in lipomas CXCR7 at 2q37 HMGA2 at 12q14

• ALK/CLTC
  23 September 2003

  ALK/CLTC fusion gene involving the clathrin gene (CLTC) and ALK
  anaplastic large-cell lymphoma (ALCL)
  diffuse large B-cell lymphoma (DLBCL) (#12763927#)
  inflammatory myofibroblastic tumor

• EWSR1-PBX1
  3 September 2008

  EWSR1/BX1
  Tumors
  EWSR1-PBX1 gen fusion in : myoepitheliomas and myoepithelial tumors
  Paywall References
  Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature. Leduc C, Zhang L, Öz B, Luo J, Fukuoka J, Antonescu CR, Travis WD. Am J Surg Pathol. 2016 Feb;40(2):212-23. doi:10.1097/PAS.0000000000000560. PMID: #26645726#
  Brandal P, Panagopoulos I, Bjerkehagen B, Gorunova L, Skjeldal S, Micci F, Heim S. Detection of a t(1;22)(q23;q12) (...)

• tyrosine kinase fusion proteins
  27 August 2008

  fusion genes involving tyrosine kinases; kinase fusions; kinase gene fusion
  The Philadelphia chromosome and the reciprocal translocation t(9;22)(q34.1;q11.23)
  The classic example of a cytogenetic abnormality leading to the formation of a chimeric fusion gene is the Philadelphia chromosome, a truncated chromosome 22 that is present in virtually all patients with chronic myeloid leukemia, in approximately 20% of patients with acute lymphoblastic leukemia, and in rare cases of acute myeloid (...)

• LPP-HMGA2
  9 October 2008

  Pathology
  LPP-HMGA2 gene fusion by t(3;12)(q27;q14-15)
  lipomas (#3349440#, #8812423#, #7670494#)
  pulmonary chondroid hamartoma (HPC)
  References
  Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG, Oliveira AM. Primary retroperitoneal lipoma: a soft tissue pathology heresy?: report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol. 2008 Jun;32(6):951-4. PMID: #18551755#
  Lemke I, Rogalla P, Grundmann F, Kunze WP, (...)

• TLS/CHOP
  3 June 2004

  TLS-CHOP

• TCF3/HLF
  2 March 2005

  Pathology
  TCF3/HLF fusion gene by t(17;19)(q22;13.3) in B-lineage acute lymphoblastic leukemia (B-ALL)
  See also
  Oncobase
  fusion genes and fusion proteins

• BIRC3/MALT1
  31 January 2005

  BIRC3-MALT1

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