Fusion proteins

Articles

• ALK/CLTC
  23 September 2003

  ALK/CLTC fusion gene involving the clathrin gene (CLTC) and ALK
  anaplastic large-cell lymphoma (ALCL)
  diffuse large B-cell lymphoma (DLBCL) (#12763927#)
  inflammatory myofibroblastic tumor

• TCF3/PBX1
  8 June 2004

  TCF3-PBX1

• EWS/ETV4
  28 June 2004

  EIAF/EWS, EWS/EIAF, ETV4/EWS

• JAZF1/JJAZ1
  28 June 2004

  JAZF1-JJAZ1

• NR4A3-TAF15
  24 August 2004

  NR4A3/TAF15
  Pathology
  NR4A3/TAF15 fusion gene by t(9;17)(q22;q11) in myxoid chondrosarcoma.

• PAX7-FOXO1
  25 November 2003

  PAX7-FKHR, PAX7/FOXO1A
  Pathology
  alveolar rhabdomyosarcoma
  References
  Collins MH, Zhao H, Womer RB, Barr FG. Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR or PAX7-FKHR gene fusions. Med Pediatr Oncol. 2001 Aug;37(2):83-9. PMID: #11496344#
  Barr FG. Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene. 2001 Sep 10;20(40):5736-46. PMID: (...)

• BCR-ABL1
  7 June 2004

  BCR-ABL, p210BCR-ABL1, Philadelphia chromosome; BCR/ABL1
  Tyrosine kinase overexpression.
  Pathology
  BCR-ABL fusion gene in B-cell acute lymphoblastic leukemia by t(9;22)(q34;q11)
  References
  Hughes T, Deininger M, Hochhaus A, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. Blood 2006;108:28-37. (...)

• MLLT3-MLL
  4 March 2004

  AF9-MLL fusion gene

• EWSR1-FLI1
  2 March 2004

  EWS/FLI-1; EWSR1/FLI1

• FUS-ERG
  2 March 2004

  FUS/ERG; ERG-FUS
  Pathology
  FUS/ERG fusion gene by t(16;21)(p11;q22) in: acute myeloid leukemia Ewing sarcoma (#12907633#)
  References
  Shing DC, McMullan DJ, Roberts P, Smith K, Chin SF, Nicholson J, Tillman RM, Ramani P, Cullinane C, Coleman N. FUS/ERG gene fusions in Ewing’s tumors. Cancer Res. 2003 Aug 1;63(15):4568-76. PMID: #12907633#

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