Fusion proteins

Articles

• EWSR1/ATF1
  15 November 2003

  ATF1/EWS, EWS/ATF1

• COL1A1-PDGFB
  21 May 2004

  COL1A1/PDGFB
  Pathology
  COL1A1-PDGFB fusion gene in dermatofibrosarcoma protuberans giant cell fibroblastoma COL1A1-PDGFB-associated uterine fibrosarcoma (#30877273#)
  See also
  COL1A1
  Paywall references
  Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms.. Croce S, Hostein I, Longacre TA, Mills AM, Pérot G, (...)

• TRC8/FHIT
  21 April 2004

  Pathology
  TRC8 gene was interrupted by a t(3;8)(p14.2;q24.1) translocation in a family with hereditary renal and non-medullary thyroid cancer (#470981#, #12522559#).
  This translocation fuses FHIT with the patched-related gene TRC8 (#9689122#) with formation of the TRC8/FHIT fusion gene.
  TRC8/FHIT fusion gene in familial renal cell carcinoma (#470981#, #9689122#)
  TRC8/FHIT fusion gene in sporadic renal cell carcinoma (...)

• NPM1-MLF1
  11 March 2004

  NPM/MLF1
  Pathology
  fusion gene in acute myeloid leukemia with t(3;5)(q25;q35)
  fusion gene in myelodysplasia with t(3;5)(q25;q35)
  See also
  NPM1
  MLF1

• CBFB/MYH11
  13 March 2004

  Pathology
  CBFB/MYH11 fusion protein in acute myeloid leukemia CBFB/MYH11 fusion protein in AML M4Eo (#12970795#)

• CXCR7-HMGA2
  27 October 2004

  HMGA2-RDC1
  Pathology
  HMGA2-CXCR7 fusion gen in lipomas CXCR7 at 2q37 HMGA2 at 12q14

• EWS/FEV
  26 October 2004

  Fusion protein created by t(2;22) in Ewing sarcoma.
  EWS/FEV joins EWS on Chr.22 and FEV on Chr.2

• BIRC3/MALT1
  31 January 2005

  BIRC3-MALT1

• FUS/CREB3L2
  4 October 2007

  FUS-CREB3L2 fusion transcript

• BRD4-NUT
  4 December 2009

  BRD4/NUT
  Definition: The protein encoded by BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Two alternatively spliced transcript variants have been described.
  Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting.
  Pathology
  BRD4-NUT poorly differentiated carcinomas ( BRD4-NUT midline carcinoma )
  BRD4 has been (...)

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